3T3 NRU phototoxicity assay| Type of assay | Phototoxicity | | Biological model | Balb/c 3T3 fibroblast cell line | | Species | Mouse | | Endpoint | Neutral red uptake |
| 3T3NRU-0001 | Toxicity | Phototoxicity | Balb/c 3T3 fibroblast cell line | Mouse | Neutral red uptake | Photometry | UVA | |
Cell monolayers, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | Currently available primary cells | | Species | | | Endpoint | MTT reduction (Preliminary assay - 8 cc) |
| CYTO-0001 | Toxicity | Cytotoxicity | Currently available primary cells | | MTT reduction (Preliminary assay - 8 cc) | Photometry | Basal | |
RHE, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | Reconstructed Epidermis, BIOalternatives RHE | | Species | Human | | Endpoint | MTT reduction |
| CYTO-0002 | Toxicity | Cytotoxicity | Reconstructed Epidermis, BIOalternatives RHE | Human | MTT reduction | Photometry | Basal | |
Skin explant, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | Skin (ex vivo) | | Species | Human | | Endpoint | MTT reduction |
| CYTO-0003 | Toxicity | Cytotoxicity | Skin (ex vivo) | Human | MTT reduction | Photometry | Basal | |
HMSC, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | Mesenchymal stem cells (hMSC) | | Species | Human | | Endpoint | MTT reduction |
| CYTO-0005 | Toxicity | Cytotoxicity | Mesenchymal stem cells (hMSC) | Human | MTT reduction | Photometry | Basal | |
Non-adherent cells, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | | | Species | Human | | Endpoint | Extracellular LDH, AlamarBlue |
| CYTO-0007 | Toxicity | Cytotoxicity | | Human | Extracellular LDH, AlamarBlue | Fluorescence, Photometry | Basal | |
HVE, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | Reconstructed Vaginal Epithelium, Skinethic | | Species | Human | | Endpoint | MTT reduction |
| CYTO-0008 | Toxicity | Cytotoxicity | Reconstructed Vaginal Epithelium, Skinethic | Human | MTT reduction | Photometry | Basal | |
Cell monolayers, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | Currently available primary cells | | Species | | | Endpoint | Neutral red uptake |
| CYTO-0009 | Toxicity | Cytotoxicity | Currently available primary cells | | Neutral red uptake | Photometry | Basal | |
Sebocytes, cytotoxicity assay (basal)| Type of assay | Cytotoxicity | | Biological model | SEBO662 sebocyte cell line, BIOalternatives | | Species | Human | | Endpoint | MTT reduction (Preliminary assay - 8 cc) |
| CYTO-0010 | Toxicity | Cytotoxicity | SEBO662 sebocyte cell line, BIOalternatives | Human | MTT reduction (Preliminary assay - 8 cc) | Photometry | Basal | |
Mast cell degranulation, histamine release (basal)| Type of assay | Pro-inflammatory compound / Immuno-reactivity, allergy | | Biological model | Mast cells (peritoneal) | | Species | Rat | | Endpoint | Histamine release |
| MAST-0002 | Short safety profile | Pro-inflammatory compound / Immuno-reactivity, allergy | Mast cells (peritoneal) | Rat | Histamine release | ELISA / EIA | Basal | |
Mo-DC, TNF- alpha release (basal)| Type of assay | Pro-inflammatory compound / Immuno-reactivity, allergy | | Biological model | Monocyte-derived dendritic cells | | Species | Human | | Endpoint | TNF- alpha release |
| MODC-0005 | Extensions | Pro-inflammatory compound / Immuno-reactivity, allergy | Monocyte-derived dendritic cells | Human | TNF- alpha release | ELISA / EIA | Basal | |
NHDF, caspase 3/7, enzymatic activity (basal)| Type of assay | Apoptosis | | Biological model | Dermal fibroblasts (NHDF) | | Species | Human | | Endpoint | Caspase 3/7 activity |
| NHDF-0052 | Safety | Apoptosis | Dermal fibroblasts (NHDF) | Human | Caspase 3/7 activity | Fluorescence | Basal | |
NHEK, IL-8 release (basal)| Type of assay | Pro-inflammatory compound / Immuno-reactivity, allergy | | Biological model | Epidermal keratinocytes (NHEK) | | Species | Human | | Endpoint | IL-8 release |
| NHEK-0084 | Short safety profile | Pro-inflammatory compound / Immuno-reactivity, allergy | Epidermal keratinocytes (NHEK) | Human | IL-8 release | ELISA / EIA | Basal | |
NHEK, TSLP release (basal)| Type of assay | Protein markers | | Biological model | Epidermal keratinocytes (NHEK) | | Species | Human | | Endpoint | TSLP release |
| NHEK-0131 | Skin sensitization | Protein markers | Epidermal keratinocytes (NHEK) | Human | TSLP release | ELISA / EIA | Basal | |
Sensory neurons, CGRP release (basal)| Type of assay | Neuromediators | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | CGRP release |
| NS-0009 | Sensitive skin, Skin sensitization, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons | Rat | CGRP release | ELISA / EIA | Basal | |
T cells, IFN- gamma release (anti-CD3 stimulation)| Type of assay | Cytokines/chemokines | | Biological model | PBMCs | | Species | Human | | Endpoint | IFN- gamma release |
| PBMC-0004 | T lymphocytes: immunostimulation, Extensions, T lymphocytes: immunostimulation, cell-mediated and humoral immunity help | Cytokines/chemokines | PBMCs | Human | IFN- gamma release | ELISA / EIA | Anti-CD3 | |
PBMC, TNF- alpha release (basal)| Type of assay | Pro-inflammatory compound / Immuno-reactivity, allergy | | Biological model | PBMCs | | Species | Human | | Endpoint | TNF- alpha release |
| PBMC-0018 | Short safety profile | Pro-inflammatory compound / Immuno-reactivity, allergy | PBMCs | Human | TNF- alpha release | ELISA / EIA | Basal | |
PBMC, IFN- gamma release (anti-CD28 stimulation)| Type of assay | Pro-inflammatory compound / Immuno-reactivity, allergy | | Biological model | PBMCs | | Species | Human | | Endpoint | IFN- gamma release |
| PBMC-0019 | Extensions | Pro-inflammatory compound / Immuno-reactivity, allergy | PBMCs | Human | IFN- gamma release | ELISA / EIA | Anti-CD28 | |
RHE phototoxicity assay| Type of assay | Phototoxicity | | Biological model | Reconstructed Epidermis, Skinethic RHE | | Species | Human | | Endpoint | MTT reduction |
| RHE-0002 | Toxicity | Phototoxicity | Reconstructed Epidermis, Skinethic RHE | Human | MTT reduction | Photometry | UVA | |
