NHEK + NHEM, TRP-1 expression (basal)| Type of assay | Melanogenic proteins | | Biological model | Keratinocytes + Melanocytes, coculture | | Species | Human | | Endpoint | TRP-1 immunolabeling |
| KM-0005 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Keratinocytes + Melanocytes, coculture | Human | TRP-1 immunolabeling | Immunofluorescence | Basal | |
RHEm, TRP-1 expression (basal)| Type of assay | Melanogenic proteins | | Biological model | Melanocyte-containing reconstructed epidermis, BIOalternatives RHEm | | Species | Human | | Endpoint | TRP-1 immunolabeling |
| RHEM-0005 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Melanocyte-containing reconstructed epidermis, BIOalternatives RHEm | Human | TRP-1 immunolabeling | Immunohistofluorescence | Basal | |
Skin maintained ex vivo, TRP-1 expression (basal)| Type of assay | Melanogenic proteins | | Biological model | Skin (ex vivo) | | Species | Human | | Endpoint | TRP-1 immunolabeling |
| SKIN-0014 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Skin (ex vivo) | Human | TRP-1 immunolabeling | Immunohistofluorescence | Basal | |
B16, tyrosinase expression (basal)| Type of assay | Melanogenic proteins | | Biological model | B16 melanoma cell line | | Species | Mouse | | Endpoint | Tyrosinase immunolabeling |
| B16-0010 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | B16 melanoma cell line | Mouse | Tyrosinase immunolabeling | Immunofluorescence | Basal | |
B16, tyrosinase expression (MSH stimulation)| Type of assay | Melanogenic proteins | | Biological model | B16 melanoma cell line | | Species | Mouse | | Endpoint | Tyrosinase immunolabeling |
| B16-0011 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | B16 melanoma cell line | Mouse | Tyrosinase immunolabeling | Immunofluorescence | NDP-MSH | |
B16, TRP-1 expression (MSH stimulation)| Type of assay | Melanogenic proteins | | Biological model | B16 melanoma cell line | | Species | Mouse | | Endpoint | TRP-1 expression |
| B16-0013 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | B16 melanoma cell line | Mouse | TRP-1 expression | Immunofluorescence | NDP-MSH | |
B16, tyrosinase activity (basal)| Type of assay | Melanogenic proteins | | Biological model | B16 melanoma cell line | | Species | Mouse | | Endpoint | Tyrosinase activity |
| B16-0014 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | B16 melanoma cell line | Mouse | Tyrosinase activity | Photometry | Basal | |
NHEK + NHEM, tyrosinase expression (basal)| Type of assay | Melanogenic proteins | | Biological model | Keratinocytes + Melanocytes, coculture | | Species | Human | | Endpoint | Tyrosinase immunolabeling |
| KM-0003 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Keratinocytes + Melanocytes, coculture | Human | Tyrosinase immunolabeling | Immunofluorescence | Basal | |
NHEM, tyrosinase expression (basal)| Type of assay | Melanogenic proteins | | Biological model | Epidermal melanocytes (NHEM) | | Species | Human | | Endpoint | Tyrosinase expression |
| NHEM-0003 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Epidermal melanocytes (NHEM) | Human | Tyrosinase expression | Immunofluorescence | Basal | |
NHEM, TRP-1 expression (basal)| Type of assay | Melanogenic proteins | | Biological model | Epidermal melanocytes (NHEM) | | Species | Human | | Endpoint | TRP-1 expression |
| NHEM-0005 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Epidermal melanocytes (NHEM) | Human | TRP-1 expression | Immunofluorescence | Basal | |
NHEM, tyrosinase activity (basal)| Type of assay | Melanogenic proteins | | Biological model | Epidermal melanocytes (NHEM) | | Species | Human | | Endpoint | Tyrosinase activity |
| NHEM-0007 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Epidermal melanocytes (NHEM) | Human | Tyrosinase activity | Photometry | Basal | |
RHEm, tyrosinase expression (basal)| Type of assay | Melanogenic proteins | | Biological model | Melanocyte-containing reconstructed epidermis, BIOalternatives RHEm | | Species | Human | | Endpoint | Tyrosinase immunolabeling |
| RHEM-0003 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Melanocyte-containing reconstructed epidermis, BIOalternatives RHEm | Human | Tyrosinase immunolabeling | IHC | Basal | |
RHEm, in situ tyrosinase activity (basal)| Type of assay | Melanogenic proteins | | Biological model | Melanocyte-containing reconstructed epidermis, BIOalternatives RHEm | | Species | Human | | Endpoint | Tyrosinase activity |
| RHEM-0007 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Melanocyte-containing reconstructed epidermis, BIOalternatives RHEm | Human | Tyrosinase activity | Immunohistofluorescence | Basal | |
Skin maintained ex vivo, in situ tyrosinase activity (basal)| Type of assay | Melanogenic proteins | | Biological model | Skin (ex vivo) | | Species | Human | | Endpoint | Tyrosinase activity |
| SKIN-0024 | Melanogenesis, Pigmentation disorders | Melanogenic proteins | Skin (ex vivo) | Human | Tyrosinase activity | In situ fluorescence | Basal | |
