RHE, skin innate immunity markers expression (cytokine stimulation)| Type of assay | Protein markers | | Biological model | Reconstructed Epidermis, BIOalternatives RHE | | Species | Human | | Endpoint | Expression of e.g. S100A7, beta-defensin 2/4, RNAse7 |
| EPIBA-0057 | Psoriasis, Psoriasis | Protein markers | Reconstructed Epidermis, BIOalternatives RHE | Human | Expression of e.g. S100A7, beta-defensin 2/4, RNAse7 | Immunohistofluorescence or IHC | IL-17 / OSM / TNF- alpha | |
RHE, IL-8 release (cytokine stimulation)| Type of assay | Protein markers | | Biological model | Reconstructed Epidermis, BIOalternatives RHE | | Species | Human | | Endpoint | IL-8 release |
| EPIBA-0058 | Psoriasis, Psoriasis | Protein markers | Reconstructed Epidermis, BIOalternatives RHE | Human | IL-8 release | ELISA / EIA | IL-17 / OSM / TNF- alpha | |
NHEK, antimicrobial peptide release (cytokine stimulation)| Type of assay | Protein markers | | Biological model | Epidermal keratinocytes (NHEK) | | Species | Human | | Endpoint | beta-defensin 2/4 release, Elafin release |
| NHEK-0009 | Psoriasis, Psoriasis | Protein markers | Epidermal keratinocytes (NHEK) | Human | beta-defensin 2/4 release, Elafin release | ELISA / EIA | IL-17 / OSM / TNF- alpha | |
NHEK, chemokine release (cytokine stimulation)| Type of assay | Protein markers | | Biological model | Epidermal keratinocytes (NHEK) | | Species | Human | | Endpoint | IL-8 release, CXCL-1 release |
| NHEK-0010 | Psoriasis, Psoriasis | Protein markers | Epidermal keratinocytes (NHEK) | Human | IL-8 release, CXCL-1 release | ELISA / EIA | IL-17 / OSM / TNF- alpha | |
NHEK, S100A7 expression (cytokine stimulation)| Type of assay | Protein markers | | Biological model | Epidermal keratinocytes (NHEK) | | Species | Human | | Endpoint | S100A7 immunolabeling |
| NHEK-0011 | Psoriasis, Psoriasis | Protein markers | Epidermal keratinocytes (NHEK) | Human | S100A7 immunolabeling | Immunofluorescence | IL-17 / OSM / TNF- alpha | |
NHEK, 4 selected protein expression (cytokine stimulation)| Type of assay | Protein markers | | Biological model | Epidermal keratinocytes (NHEK) | | Species | Human | | Endpoint | beta-defensin, IL-8, S100A7, KRT10 |
| NHEK-0013 | Psoriasis, Psoriasis | Protein markers | Epidermal keratinocytes (NHEK) | Human | beta-defensin, IL-8, S100A7, KRT10 | Immunofluorescence + ELISA | IL-17 / OSM / TNF- alpha | |
