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NHEK-0030 - NHEK, JNK activation (OSM stimulation)

NHEK, JNK activation (OSM stimulation)
Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointJNK phosphorylation
MethodWestern blot
Stimulating factor / inducerOncostatin M
Reference compoundSP600125
Physio-pathologyPsoriasis, Psoriasis
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Plus d'options Reference Physio-pathology Type of assay Biological model Species Endpoint Method Stimulating factor / inducer
NHEK, JNK activation (cytokine stimulation)

NHEK, JNK activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointJNK phosphorylation
NHEK-0029Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanJNK phosphorylationWestern blotIL-17 / OSM / TNF- alpha
NHEK, JNK activation (cytokine stimulation)

NHEK, JNK activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointJNK phosphorylation
NHEK-0031Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanJNK phosphorylationFlow cytometry (CBA)IL-17 / OSM / TNF- alpha
NHEK, NF kappaB translocation (cytokine stimulation)

NHEK, NF kappaB translocation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointNF kappaB translocation
NHEK-0014Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanNF kappaB translocationImmunofluorescenceIL-17 / OSM / TNF- alpha
NHEK, NF kappaB translocation (TNF- alpha stimulation)

NHEK, NF kappaB translocation (TNF- alpha stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointNF kappaB translocation
NHEK-0015Psoriasis, Atopic dermatitis, Psoriasis, Atopic dermatitisSignal transductionEpidermal keratinocytes (NHEK)HumanNF kappaB translocationImmunofluorescenceTNF- alpha
NHEK, STAT1 activation (cytokine stimulation)

NHEK, STAT1 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT1 phosphorylation
NHEK-0016Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT1 phosphorylationWestern blotIL-17 / OSM / TNF- alpha
NHEK, STAT1 activation (OSM stimulation)

NHEK, STAT1 activation (OSM stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT1 phosphorylation
NHEK-0017Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT1 phosphorylationWestern blotOncostatin M
NHEK, STAT1 activation (cytokine stimulation)

NHEK, STAT1 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT1 phosphorylation
NHEK-0018Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT1 phosphorylationFlow cytometry (CBA)IL-17 / OSM / TNF- alpha
NHEK, STAT3 activation (cytokine stimulation)

NHEK, STAT3 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT3 phosphorylation
NHEK-0019Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT3 phosphorylationWestern blotIL-17 / OSM / TNF- alpha
NHEK, STAT3 activation (OSM stimulation)

NHEK, STAT3 activation (OSM stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT3 phosphorylation
NHEK-0020Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT3 phosphorylationWestern blotOncostatin M
NHEK, STAT3 activation (cytokine stimulation)

NHEK, STAT3 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT3 phosphorylation
NHEK-0021Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT3 phosphorylationFlow cytometry (CBA)IL-17 / OSM / TNF- alpha
NHEK, STAT3 activation (cytokine stimulation)

NHEK, STAT3 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT3 phosphorylation / translocation
NHEK-0022Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT3 phosphorylation / translocationImmunofluorescenceIL-17 / OSM / TNF- alpha
NHEK, STAT3 activation (OSM stimulation)

NHEK, STAT3 activation (OSM stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT3 phosphorylation / translocation
NHEK-0023Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT3 phosphorylation / translocationImmunofluorescenceOSM
NHEK, p38 activation (cytokine stimulation)

NHEK, p38 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
Endpointp38 phosphorylation
NHEK-0024Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)Humanp38 phosphorylationWestern blotIL-17 / OSM / TNF- alpha
NHEK, p38 activation (IL-1 alpha stimulation)

NHEK, p38 activation (IL-1 alpha stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
Endpointp38 phosphorylation
NHEK-0025Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)Humanp38 phosphorylationWestern blotIL-1 alpha
NHEK, p38 activation (cytokine stimulation)

NHEK, p38 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
Endpointp38 phosphorylation
NHEK-0026Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)Humanp38 phosphorylationFlow cytometry (CBA)IL-17 / OSM / TNF- alpha
NHEK, ERK1/2 activation (cytokine stimulation)

NHEK, ERK1/2 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointERK1/2 phosphorylation
NHEK-0027Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanERK1/2 phosphorylationWestern blotIL-17 / OSM / TNF- alpha
NHEK, ERK1/2 activation (OSM stimulation)

NHEK, ERK1/2 activation (OSM stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointERK1/2 phosphorylation
NHEK-0028Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanERK1/2 phosphorylationWestern blotOncostatin M
NHEK, STAT3 activation (OSM stimulation)

NHEK, STAT3 activation (OSM stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointSTAT3 phosphorylation
NHEK-0041Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanSTAT3 phosphorylationFlow cytometry (CBA)OSM
NHEK, ERK1/2 activation (cytokine stimulation)

NHEK, ERK1/2 activation (cytokine stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointERK1/2 phosphorylation
NHEK-0042Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanERK1/2 phosphorylationFlow cytometry (CBA)IL-17 / OSM / TNF- alpha
NHEK, ERK1/2 activation (OSM stimulation)

NHEK, ERK1/2 activation (OSM stimulation)

Type of assaySignal transduction
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointERK1/2 phosphorylation
NHEK-0043Psoriasis, PsoriasisSignal transductionEpidermal keratinocytes (NHEK)HumanERK1/2 phosphorylationFlow cytometry (CBA)OSM
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