RHE, IL-8 release (PMA stimulation) Type of assay Cytokines/chemokines Biological model Reconstructed Epidermis, BIOalternatives RHE Species Human Endpoint IL-8 release
EPIBA-0001 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Cytokines/chemokines Reconstructed Epidermis, BIOalternatives RHE Human IL-8 release ELISA / EIA PMA RHE, PGE2 release (PMA stimulation) Type of assay Arachidonic acid metabolites Biological model Reconstructed Epidermis, BIOalternatives RHE Species Human Endpoint PGE2 release
EPIBA-0002 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Arachidonic acid metabolites Reconstructed Epidermis, BIOalternatives RHE Human PGE2 release ELISA / EIA PMA RHE, gene expression (PMA stimulation) Type of assay Gene expression Biological model Reconstructed Epidermis, BIOalternatives RHE Species Human Endpoint Your gene(s) of interest (RT-qPCR), mQPA-INFLAM-TISSUE-64
EPIBA-0061 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Gene expression Reconstructed Epidermis, BIOalternatives RHE Human Your gene(s) of interest (RT-qPCR), mQPA-INFLAM-TISSUE-64 RT-qPCR, qPCRarray (standard or customized) PMA NCTC 2544, IL-8 release (PMA stimulation) Type of assay Cytokines/chemokines Biological model NCTC 2544 cell line Species Human Endpoint IL-8 release
NCTC-0001 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Cytokines/chemokines NCTC 2544 cell line Human IL-8 release ELISA / EIA PMA NCTC 2544, PGE2 release (PMA stimulation) Type of assay Arachidonic acid metabolites Biological model NCTC 2544 cell line Species Human Endpoint PGE2 release
NCTC-0002 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Arachidonic acid metabolites NCTC 2544 cell line Human PGE2 release ELISA / EIA PMA NHDF, IL-6 release (IL-1 alpha stimulation) Type of assay Cytokines/chemokines Biological model Dermal fibroblasts (NHDF) Species Human Endpoint IL-6 release
NHDF-0087 Keratinocyte response to small bioactive molecules Cytokines/chemokines Dermal fibroblasts (NHDF) Human IL-6 release ELISA / EIA IL-1 alpha NHDF, IL-8 release (IL-1 alpha stimulation) Type of assay Cytokines/chemokines Biological model Dermal fibroblasts (NHDF) Species Human Endpoint IL-8 release
NHDF-0088 Keratinocyte response to small bioactive molecules Cytokines/chemokines Dermal fibroblasts (NHDF) Human IL-8 release ELISA / EIA IL-1 alpha NHEK, IL-8 release (PMA stimulation) Type of assay Cytokines/chemokines Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint IL-8 release
NHEK-0001 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Cytokines/chemokines Epidermal keratinocytes (NHEK) Human IL-8 release ELISA / EIA PMA NHEK, cAMP content (forskolin stimulation) Type of assay Signal transduction Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint cAMP content
NHEK-0032 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Signal transduction Epidermal keratinocytes (NHEK) Human cAMP content HTRF Forskolin NHEK, calcium mobilization (bradykinin stimulation) Type of assay Signal transduction Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint Calcium mobilization
NHEK-0048 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Signal transduction Epidermal keratinocytes (NHEK) Human Calcium mobilization Time-lapse microscopy Bradykinin NHEK, calcium mobilization (basal) Type of assay Signal transduction Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint Calcium mobilization
NHEK-0141 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Signal transduction Epidermal keratinocytes (NHEK) Human Calcium mobilization Time-lapse microscopy Basal NHEK, calcium mobilization (histamine stimulation) Type of assay Signal transduction Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint Calcium mobilization
NHEK-0145 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules, Atopic dermatitis, Atopic dermatitis Signal transduction Epidermal keratinocytes (NHEK) Human Calcium mobilization Time-lapse microscopy Histamine NHEK, calcium mobilization (basal) Type of assay Signal transduction Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint Calcium mobilization
NHEK-0146 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Signal transduction Epidermal keratinocytes (NHEK) Human Calcium mobilization Time-lapse microscopy Basal NHEK, gene expression (PMA stimulation) Type of assay Gene expression Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint Your gene(s) of interest (RT-qPCR), mQPA-INFLAM-TISSUE-64, mQPA-NHEK-64
NHEK-0159 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Gene expression Epidermal keratinocytes (NHEK) Human Your gene(s) of interest (RT-qPCR), mQPA-INFLAM-TISSUE-64, mQPA-NHEK-64 RT-qPCR, qPCRarray (standard or customized) PMA NHEK, gene expression (Poly(I:C) stimulation) Type of assay Gene expression Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint qPCRarray (16 genes)
NHEK-0163 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Gene expression Epidermal keratinocytes (NHEK) Human qPCRarray (16 genes) qPCRarray (standard or customized) Poly(I:C) NHEK, cytokine/chemokine release (poly(I:C) stimulation) Type of assay Cytokines/chemokines Biological model Epidermal keratinocytes (NHEK) Species Human Endpoint IL-6 release, CXCL8/IL-8 release, CCL20 release
NHEK-0164 Keratinocyte inflammatory response to small bioactive molecules, Keratinocyte response to small bioactive molecules Cytokines/chemokines Epidermal keratinocytes (NHEK) Human IL-6 release, CXCL8/IL-8 release, CCL20 release ELISA / EIA Poly(I:C) Skin maintained ex vivo, PGE2 release (arachidonic acid stimulation) Type of assay Arachidonic acid metabolites Biological model Skin (ex vivo) Species Human Endpoint PGE2 release
SKIN-0043 Keratinocyte response to small bioactive molecules Arachidonic acid metabolites Skin (ex vivo) Human PGE2 release ELISA / EIA Arachidonic acid
