NHEM, melanocyte dendricity (basal) Type of assay Melanocyte dendricity Biological model Epidermal melanocytes (NHEM) Species Human Endpoint TRP-1 immunolabeling
NHEM-0013 Melanin transfer, Pigmentation disorders Melanocyte dendricity Epidermal melanocytes (NHEM) Human TRP-1 immunolabeling Immunofluorescence Basal NHEM, proliferation (basal) Type of assay Proliferation Biological model Epidermal melanocytes (NHEM) Species Human Endpoint Proliferation
NHEM-0016 Melanogenesis, Pigmentation disorders Proliferation Epidermal melanocytes (NHEM) Human Proliferation BrdU incorporation / Photometry Basal Sensory neurons, neurite outgrowth (basal) Type of assay Neurite outgrowth Biological model Sensory neurons Species Rat Endpoint beta-III tubulin labeling
NS-0001 Wound healing, trauma & agressions, Neurodegenerative diseases, Wound healing, trauma & aggressions Neurite outgrowth Sensory neurons Rat beta-III tubulin labeling Immunofluorescence Basal Sensory neurons, calcium mobilization (histamine stimulation) Type of assay Signal transduction Biological model Sensory neurons Species Rat Endpoint Calcium mobilization
NS-0002 Sensitive skin, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Signal transduction Sensory neurons Rat Calcium mobilization Time-lapse microscopy Histamine Sensory neurons, calcium mobilization (capsaicin stimulation) Type of assay Signal transduction Biological model Sensory neurons Species Rat Endpoint Calcium mobilization
NS-0003 Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Signal transduction Sensory neurons Rat Calcium mobilization Time-lapse microscopy Capsaicin Sensory neurons, CGRP release (capsaicin stimulation) Type of assay Neuromediators Biological model Sensory neurons Species Rat Endpoint CGRP release
NS-0004 Sensitive skin, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Neuromediators Sensory neurons Rat CGRP release ELISA / EIA Capsaicin Sensory neurons, substance P release (capsaicin stimulation) Type of assay Neuromediators Biological model Sensory neurons Species Rat Endpoint Substance P release
NS-0005 Sensitive skin, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Neuromediators Sensory neurons Rat Substance P release ELISA / EIA Capsaicin Sensory neurons, delta opioid receptor expression (basal) Type of assay Neuromediators Biological model Sensory neurons Species Rat Endpoint Delta opioid receptor expression
NS-0010 Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Neuromediators Sensory neurons Rat Delta opioid receptor expression Immunofluorescence Basal Sensory neurons, substance P release (Basal) Type of assay Neuromediators Biological model Sensory neurons Species Rat Endpoint Substance P release
NS-0011 Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Neuromediators Sensory neurons Rat Substance P release ELISA / EIA Basal Sensory neurons+NHEK, CGRP release (capsaicin stimulation) Type of assay Neuromediators Biological model Sensory neurons + Keratinocytes, coculture Species Rat / Human Endpoint CGRP release
NSK-0001 Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Neuromediators Sensory neurons + Keratinocytes, coculture Rat / Human CGRP release ELISA / EIA Capsaicin Sensory neurons+NHEK, substance P release (capsaicin stimulation) Type of assay Neuromediators Biological model Sensory neurons + Keratinocytes, coculture Species Rat / Human Endpoint Substance P release
NSK-0002 Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching Neuromediators Sensory neurons + Keratinocytes, coculture Rat / Human Substance P release ELISA / EIA Capsaicin T cell proliferation (PHA stimulation) Type of assay Proliferation and/or migration Biological model PBMCs Species Human Endpoint Proliferation
PBMC-0001 T lymphocytes: anti-inflammatory effects/immunosuppression, T lymphocytes: anti-inflammatory effects/immunosuppression - cell-mediated and humoral immunity modulation Proliferation and/or migration PBMCs Human Proliferation [3H]-thymidine incorporation PHA T cells, CD25 expression (PHA stimulation) Type of assay Activation markers Biological model PBMCs Species Human Endpoint CD25 expression
PBMC-0002 T lymphocytes: anti-inflammatory effects/immunosuppression, T lymphocytes: anti-inflammatory effects/immunosuppression - cell-mediated and humoral immunity modulation Activation markers PBMCs Human CD25 expression Flow cytometry PHA T cells, IFN- gamma release (basal) Type of assay Cytokines/chemokines Biological model PBMCs Species Human Endpoint IFN- gamma release
PBMC-0003 T lymphocytes: immunostimulation, T lymphocytes: immunostimulation, cell-mediated and humoral immunity help Cytokines/chemokines PBMCs Human IFN- gamma release ELISA / EIA Basal T cells, IFN- gamma release (anti-CD3 stimulation) Type of assay Cytokines/chemokines Biological model PBMCs Species Human Endpoint IFN- gamma release
PBMC-0004 T lymphocytes: immunostimulation, Extensions, T lymphocytes: immunostimulation, cell-mediated and humoral immunity help Cytokines/chemokines PBMCs Human IFN- gamma release ELISA / EIA Anti-CD3 Monocytes, cytokine release (LPS stimulation) Type of assay Inflammatory cytokines Biological model PBMCs Species Human Endpoint TNF- alpha release, IL-8 release, IL-6 release, or other inflammatory cytokines, IL-12 release
PBMC-0005 Monocytes/macrophages, Monocytes/macrophages: inflammation, innate immunity Inflammatory cytokines PBMCs Human TNF- alpha release, IL-8 release, IL-6 release, or other inflammatory cytokines, IL-12 release ELISA / EIA LPS PBMC, O2- content (PMA stimulation) Type of assay Free radicals Biological model PBMCs Species Human Endpoint O2- (cellular), Hydroxyethidine probe
PBMC-0007 Monocytes/macrophages, Monocytes/macrophages: inflammation, innate immunity Free radicals PBMCs Human O2- (cellular), Hydroxyethidine probe Flow cytometry PMA T cells, cytokine release (anti-CD3/anti-CD28 stimulation) Type of assay Th1 polarity - Cytokines Biological model PBMCs Species Human Endpoint IFN- gamma release, TNF- alpha release, or other Th1 cytokines, IL-2 release
PBMC-0008 T lymphocytes: anti-inflammatory effects/immunosuppression, T lymphocytes: anti-inflammatory effects/immunosuppression - cell-mediated and humoral immunity modulation Th1 polarity - Cytokines PBMCs Human IFN- gamma release, TNF- alpha release, or other Th1 cytokines, IL-2 release ELISA / EIA Anti-CD3 / Anti-CD28 T cells, cytokine release (anti-CD3/anti-CD28 stimulation) Type of assay Th2 polarity - Cytokines Biological model PBMCs Species Human Endpoint TNF- alpha release, IL-10 release, or other Th2 cytokines
PBMC-0009 T lymphocytes: anti-inflammatory effects/immunosuppression, Atopic dermatitis, Atopic dermatitis, T lymphocytes: anti-inflammatory effects/immunosuppression - cell-mediated and humoral immunity modulation Th2 polarity - Cytokines PBMCs Human TNF- alpha release, IL-10 release, or other Th2 cytokines ELISA / EIA Anti-CD3 / Anti-CD28 T cells, cytokine release (anti-CD3/anti-CD28 stimulation) Type of assay Th17 polarity - Cytokines Biological model PBMCs Species Human Endpoint IL-17 release, or other Th17 cytokines
PBMC-0010 T lymphocytes: anti-inflammatory effects/immunosuppression, Psoriasis, Psoriasis, T lymphocytes: anti-inflammatory effects/immunosuppression - cell-mediated and humoral immunity modulation Th17 polarity - Cytokines PBMCs Human IL-17 release, or other Th17 cytokines ELISA / EIA Anti-CD3 / Anti-CD28
