Astrocytes, chemokine production (cytokine stimulation)| Type of assay | Cytokines/chemokines | | Biological model | Astrocytes | | Species | Mouse | | Endpoint | CCL5 release |
| ASTRO-0001 | CNS inflammation | Cytokines/chemokines | Astrocytes | Mouse | CCL5 release | ELISA / EIA | IL-1 beta / IL-6 / TNF- alpha | |
COMT activity| Type of assay | Metabolism | | Biological model | Acellular | | Species | Human | | Endpoint | Catecholamine-O-methyl transferase activity |
| BIOCH-0001 | Enzyme activity assays, Neurodegenerative diseases, Parkinson's disease | Metabolism | Acellular | Human | Catecholamine-O-methyl transferase activity | Fluorescence | | |
Microglia, cytokine release (LPS stimulation)| Type of assay | Cytokines/chemokines | | Biological model | Brain microglial cells (BMC) | | Species | Rat | | Endpoint | TNF- alpha release, IL-1 beta release, IL-6 release |
| BMC-0001 | CNS inflammation | Cytokines/chemokines | Brain microglial cells (BMC) | Rat | TNF- alpha release, IL-1 beta release, IL-6 release | ELISA / EIA | LPS | |
Microglia, NO production (LPS stimulation)| Type of assay | Free radicals | | Biological model | Brain microglial cells (BMC) | | Species | Rat | | Endpoint | Nitrite determination |
| BMC-0002 | CNS inflammation | Free radicals | Brain microglial cells (BMC) | Rat | Nitrite determination | Greiss reagent | LPS | |
DRG network (basal)| Type of assay | Neurite outgrowth | | Biological model | Dorsal root ganglia (DRG) | | Species | Rat | | Endpoint | beta-III tubulin labeling |
| DRG-0001 | Wound healing, trauma & agressions, Neurodegenerative diseases, Wound healing, trauma & aggressions | Neurite outgrowth | Dorsal root ganglia (DRG) | Rat | beta-III tubulin labeling | Immunofluorescence | Basal | |
DRG network (cisplatin-intoxicated)| Type of assay | Cisplatin intoxication | | Biological model | Dorsal root ganglia (DRG) | | Species | Rat | | Endpoint | beta-III tubulin labeling |
| DRG-0002 | Peripheral neuropathies | Cisplatin intoxication | Dorsal root ganglia (DRG) | Rat | beta-III tubulin labeling | Immunofluorescence | Cisplatin | |
Mast cells degranulation, histamine release (compound 48/80 stimulation)| Type of assay | Degranulation | | Biological model | Mast cells (peritoneal) | | Species | Rat | | Endpoint | Histamine release |
| MAST-0001 | Sensitive skin, Basophils/Mast cells, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Mast cells: allergy, inflammation, B cell help, Peripheral inflammation, sensitivity, pain, itching | Degranulation | Mast cells (peritoneal) | Rat | Histamine release | ELISA / EIA | CP48/80 | |
Oligodendrocytes + cortical neurons, myelination (basal)| Type of assay | Myelination assay | | Biological model | Cortical Neurons & Oligodendrocytes & Astrocytes, mixed culture | | Species | Rat | | Endpoint | MBP / beta-III tubulin |
| NCOD-0001 | Demyelinating diseases & multiple sclerosis | Myelination assay | Cortical Neurons & Oligodendrocytes & Astrocytes, mixed culture | Rat | MBP / beta-III tubulin | Immunofluorescence | Basal | |
Cortical neurons, neurite outgrowth (basal)| Type of assay | Neurite outgrowth | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | beta-III tubulin labeling |
| NCOR-0001 | Neurodegenerative diseases, Ischemia & Stroke | Neurite outgrowth | Cortical neurons | Rat | beta-III tubulin labeling | Immunofluorescence | Basal | |
Cortical neuron network (glutamate-intoxicated)| Type of assay | Glutamate neurotoxicity | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | NF-H labeling |
| NCOR-0002 | Ischemia & Stroke, Epilepsy | Glutamate neurotoxicity | Cortical neurons | Rat | NF-H labeling | Immunofluorescence | Glutamate | |
Cortical neuron network (A beta 1-42 - intoxicated)| Type of assay | Amyloid beta neurotoxicity | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | beta-III tubulin labeling, Active caspase 3 labeling |
| NCOR-0003 | Alzheimer's disease | Amyloid beta neurotoxicity | Cortical neurons | Rat | beta-III tubulin labeling, Active caspase 3 labeling | Immunofluorescence | A beta 1-42 | |
Cortical neuron network (O2-deprivated)| Type of assay | O2 / glucose deprivation | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | MAP-2 labeling |
| NCOR-0004 | Ischemia & Stroke | O2 / glucose deprivation | Cortical neurons | Rat | MAP-2 labeling | Immunofluorescence | O2 deprivation | |
Cortical neuron network (glucose-deprivated)| Type of assay | O2 / glucose deprivation | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | MAP-2 labeling |
| NCOR-0005 | Ischemia & Stroke | O2 / glucose deprivation | Cortical neurons | Rat | MAP-2 labeling | Immunofluorescence | Glucose deprivation | |
Cortical neuron network (O2 and glucose-deprivated)| Type of assay | O2 / glucose deprivation | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | MAP-2 labeling |
| NCOR-0006 | Ischemia & Stroke | O2 / glucose deprivation | Cortical neurons | Rat | MAP-2 labeling | Immunofluorescence | O2 and glucose deprivation | |
Cortical neuron network (H2O2-intoxicated)| Type of assay | H202 neurotoxicity | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | beta-III tubulin labeling |
| NCOR-0007 | Ischemia & Stroke | H202 neurotoxicity | Cortical neurons | Rat | beta-III tubulin labeling | Immunofluorescence | H2O2 | |
Cortical neurons, neuritogenesis (basal)| Type of assay | Neurite outgrowth | | Biological model | Cortical neurons | | Species | Rat | | Endpoint | Calcein-AM probe |
| NCOR-0008 | Neurodegenerative diseases | Neurite outgrowth | Cortical neurons | Rat | Calcein-AM probe | Fluorescence / imaging | Basal | |
Dopaminergic neurons (6-OHDA-intoxicated)| Type of assay | 6-Hydroxydopamine neurotoxicity | | Biological model | Dopaminergic neurons | | Species | Rat | | Endpoint | Tyrosine hydroxylase labeling |
| NDOPA-0002 | Parkinson's disease | 6-Hydroxydopamine neurotoxicity | Dopaminergic neurons | Rat | Tyrosine hydroxylase labeling | Immunofluorescence | 6-OHDA | |
Hippocampal neuron network (A beta 1-42 - intoxicated)| Type of assay | Amyloid beta neurotoxicity | | Biological model | Hippocampal neurons | | Species | Rat | | Endpoint | beta-III tubulin labeling, Active caspase 3 labeling |
| NHIPP-0001 | Alzheimer's disease | Amyloid beta neurotoxicity | Hippocampal neurons | Rat | beta-III tubulin labeling, Active caspase 3 labeling | Immunofluorescence | A beta 1-42 | |
Hippocampal neurons, neuritogenesis (basal)| Type of assay | Neurite outgrowth | | Biological model | Hippocampal neurons | | Species | Rat | | Endpoint | Calcein-AM probe |
| NHIPP-0003 | Neurodegenerative diseases, Ischemia & Stroke | Neurite outgrowth | Hippocampal neurons | Rat | Calcein-AM probe | Fluorescence / imaging | Basal | |
Hippocampal neuron network (glutamate-intoxicated)| Type of assay | Glutamate neurotoxicity | | Biological model | Hippocampal neurons | | Species | Rat | | Endpoint | NF-H labeling |
| NHIPP-0004 | Ischemia & Stroke, Epilepsy | Glutamate neurotoxicity | Hippocampal neurons | Rat | NF-H labeling | Immunofluorescence | Glutamate | |
