DPF, testosterone metabolism & 5- alpha reductase activity (basal)| Type of assay | Androgen metabolism | | Biological model | Human Follicle Dermal Papilla Cells(HFDPC) | | Species | Human | | Endpoint | 5- alpha reductase activity |
| DPF-0001 | Hair growth & degeneration | Androgen metabolism | Human Follicle Dermal Papilla Cells(HFDPC) | Human | 5- alpha reductase activity | [14C]-testosterone incorporation | Basal | |
RHE, testosterone metabolism & 5- alpha reductase activity (basal)| Type of assay | Androgen metabolism | | Biological model | Reconstructed Epidermis, BIOalternatives RHE | | Species | Human | | Endpoint | 5- alpha reductase activity |
| EPIBA-0052 | Hair growth & degeneration, Acne, Acne | Androgen metabolism | Reconstructed Epidermis, BIOalternatives RHE | Human | 5- alpha reductase activity | [14C]-testosterone incorporation | Basal | |
Hair follicle growth (basal)| Type of assay | Morphology | | Biological model | Hair follicle | | Species | Human | | Endpoint | Growth measurement for at least 12 days |
| FOLL-0001 | Hair growth & degeneration | Morphology | Hair follicle | Human | Growth measurement for at least 12 days | Imaging | Basal | |
Hair follicle growth & degeneration (basal)| Type of assay | Morphology | | Biological model | Hair follicle | | Species | Human | | Endpoint | Growth measurement & Morphology until apoptosis |
| FOLL-0002 | Hair growth & degeneration | Morphology | Hair follicle | Human | Growth measurement & Morphology until apoptosis | Imaging | Basal | |
Hair follicle, protein expression (basal)| Type of assay | Protein markers | | Biological model | Hair follicle | | Species | Human | | Endpoint | Hair protein markers, e.g. TGK, fibronectin, ... |
| FOLL-0003 | Hair growth & degeneration | Protein markers | Hair follicle | Human | Hair protein markers, e.g. TGK, fibronectin, ... | Immunohistofluorescence | Basal | |
Hair follicle, gene expression (basal)| Type of assay | Gene expression | | Biological model | Hair follicle | | Species | Human | | Endpoint | Selection of genes of interest, mQPA-HAIR |
| FOLL-0004 | Hair growth & degeneration | Gene expression | Hair follicle | Human | Selection of genes of interest, mQPA-HAIR | RT-qPCR, qPCRarray (standard or customized) | Basal | |
Hair follicle, testosterone metabolism & 5- alpha reductase activity (basal)| Type of assay | Androgen metabolism | | Biological model | Hair follicle | | Species | Human | | Endpoint | 5- alpha reductase activity |
| FOLL-0006 | Hair growth & degeneration | Androgen metabolism | Hair follicle | Human | 5- alpha reductase activity | [14C]-testosterone incorporation | Basal | |
Hair follicle, pigmentation-related gene expression (basal)| Type of assay | Gene expression | | Biological model | Hair follicle | | Species | Human | | Endpoint | mRNA: e.g. TYR, TRP1, MITF, MC1R,..., mQPA-HAIR |
| FOLL-0009 | Hair pigmentation, Melanogenesis, Pigmentation disorders | Gene expression | Hair follicle | Human | mRNA: e.g. TYR, TRP1, MITF, MC1R,..., mQPA-HAIR | RT-qPCR, qPCRarray (standard or customized) | Basal | |
Hair follicle, pigmentation (Fontana Masson staining)| Type of assay | Melanin synthesis | | Biological model | Hair follicle | | Species | Human | | Endpoint | Melanin staining |
| FOLL-0011 | Hair pigmentation | Melanin synthesis | Hair follicle | Human | Melanin staining | Histology (Fontana-Masson staining) | Basal | |
NHDF, testosterone metabolism & 5- alpha reductase activity (basal)| Type of assay | Androgen metabolism | | Biological model | Dermal fibroblasts (NHDF) | | Species | Human | | Endpoint | 5- alpha reductase activity |
| NHDF-0050 | Hair growth & degeneration, Acne, Acne | Androgen metabolism | Dermal fibroblasts (NHDF) | Human | 5- alpha reductase activity | [14C]-testosterone incorporation | Basal | |
NHEK, testosterone metabolism & 5- alpha reductase activity (basal)| Type of assay | Androgen metabolism | | Biological model | Epidermal keratinocytes (NHEK) | | Species | Human | | Endpoint | 5- alpha reductase activity |
| NHEK-0124 | Hair growth & degeneration, Acne, Acne | Androgen metabolism | Epidermal keratinocytes (NHEK) | Human | 5- alpha reductase activity | [14C]-testosterone incorporation | Basal | |
