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Plus d'options Reference Physio-pathology Type of assay Biological model Species Endpoint Method Stimulating factor / inducer
MMP-1 inhibition (recombinant enzyme)

MMP-1 inhibition (recombinant enzyme)

Type of assayEnzyme activity
Biological modelAcellular
SpeciesHuman
EndpointHuman MMP-1 activity
BIOCH-0002Enzyme activity assays, ECM degradationEnzyme activityAcellularHumanHuman MMP-1 activityFluorescence
MMP-9 inhibition (recombinant enzyme)

MMP-9 inhibition (recombinant enzyme)

Type of assayEnzyme activity
Biological modelAcellular
SpeciesHuman
EndpointHuman MMP-9 activity
BIOCH-0003Enzyme activity assays, ECM degradationEnzyme activityAcellularHumanHuman MMP-9 activityFluorescence
MMP inhibition (NHDF extracts)

MMP inhibition (NHDF extracts)

Type of assayEnzyme activity
Biological modelAcellular
SpeciesHuman
EndpointHuman MMP activity (2 substrates)*, Human MMP-2 and MMP-7 activity, Human MMP-1, MMP-8, MMP-13 and MMP-14 activity
BIOCH-0004Enzyme activity assays, ECM degradationEnzyme activityAcellularHumanHuman MMP activity (2 substrates)*, Human MMP-2 and MMP-7 activity, Human MMP-1, MMP-8, MMP-13 and MMP-14 activityFluorescence
Hyaluronidase inhibition (purified enzyme)

Hyaluronidase inhibition (purified enzyme)

Type of assayEnzyme activity
Biological modelAcellular
SpeciesBovine
EndpointHyaluronidase activity
BIOCH-0005Enzyme activity assays, Epidermal matrix, hydration, ECM degradationEnzyme activityAcellularBovineHyaluronidase activityPhotometryBasal
Leukocyte elastase inhibition (purified enzyme)

Leukocyte elastase inhibition (purified enzyme)

Type of assayEnzyme activity
Biological modelAcellular
SpeciesHuman
EndpointElastase activity (serine-type enzyme)
BIOCH-0006Enzyme activity assays, ECM degradationEnzyme activityAcellularHumanElastase activity (serine-type enzyme)Fluorescence
Collagenase inhibition (bacterial enzyme)

Collagenase inhibition (bacterial enzyme)

Type of assayEnzyme activity
Biological modelAcellular
Species
EndpointCollagenase activity
BIOCH-0021Enzyme activity assays, ECM degradationEnzyme activityAcellularCollagenase activityFluorescence
MMP-2 inhibition (recombinant enzyme)

MMP-2 inhibition (recombinant enzyme)

Type of assayEnzyme activity
Biological modelAcellular
SpeciesHuman
EndpointHuman MMP-2 activity
BIOCH-0028Enzyme activity assays, ECM degradationEnzyme activityAcellularHumanHuman MMP-2 activityFluorescence
DE, dermis strength and cohesion (basal)

DE, dermis strength and cohesion (basal)

Type of assayMetabolism
Biological modelDermis-equivalent, normal fibroblasts
SpeciesHuman
EndpointLattices contraction
DE-0001Fibroblast viability & metabolismMetabolismDermis-equivalent, normal fibroblastsHumanLattices contractionImagingBasal
DE, hyaluronic acid synthesis/release (basal)

DE, hyaluronic acid synthesis/release (basal)

Type of assayGAG synthesis
Biological modelDermis-equivalent, normal fibroblasts
SpeciesHuman
EndpointHyaluronic acid synthesis / release
DE-0006ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsGAG synthesisDermis-equivalent, normal fibroblastsHumanHyaluronic acid synthesis / releaseELISA / EIABasal
DE, total GAGs neosynthesis (basal)

DE, total GAGs neosynthesis (basal)

Type of assayGAG synthesis
Biological modelDermis-equivalent, normal fibroblasts
SpeciesHuman
EndpointGlycosaminoglycans (GAGs, total)
DE-0008ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsGAG synthesisDermis-equivalent, normal fibroblastsHumanGlycosaminoglycans (GAGs, total)[3H]-glucosamine incorporationBasal
DE, fibroblast & ECM-related gene expression (basal)

DE, fibroblast & ECM-related gene expression (basal)

Type of assayGene expression
Biological modelDermis-equivalent, normal fibroblasts
SpeciesHuman
EndpointmRNA: e.g. ECM-related genes,..., mQPA-NHDF-16, mQPA-NHDF-32, mQPA-NHDF-64
DE-0010ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsGene expressionDermis-equivalent, normal fibroblastsHumanmRNA: e.g. ECM-related genes,..., mQPA-NHDF-16, mQPA-NHDF-32, mQPA-NHDF-64RT-qPCR, qPCRarray (standard or customized)Basal
NHDF, MMP-1 release (UV stimulation)

NHDF, MMP-1 release (UV stimulation)

Type of assayECM synthesis/degradation
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointMMP-1 release
NHDF-0001ECM degradation, Photo-aging (dermis), Photo-aging, UV, solar (dermis)ECM synthesis/degradationDermal fibroblasts (NHDF)HumanMMP-1 releaseELISA / EIAUVA
NHDF, proliferation (basal)

NHDF, proliferation (basal)

Type of assayProliferation and/or migration
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointProliferation
NHDF-0003Fibroblast viability & metabolism, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsProliferation and/or migrationDermal fibroblasts (NHDF)HumanProliferation[3H]-thymidine incorporationBasal
NHDF, migration (basal)

NHDF, migration (basal)

Type of assayProliferation and/or migration
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointMigration, Migration (+ proliferation)
NHDF-0004Fibroblast viability & metabolism, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsProliferation and/or migrationDermal fibroblasts (NHDF)HumanMigration, Migration (+ proliferation)Fluorescence / imagingBasal
NHDF, procollagen I synthesis/release (basal)

NHDF, procollagen I synthesis/release (basal)

Type of assayProtein markers
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointProcollagen I synthesis / release
NHDF-0006ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsProtein markersDermal fibroblasts (NHDF)HumanProcollagen I synthesis / releaseELISA / EIABasal
NHDF, fibronectin synthesis/release (basal)

NHDF, fibronectin synthesis/release (basal)

Type of assayProtein markers
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointFibronectin synthesis / release
NHDF-0007ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsProtein markersDermal fibroblasts (NHDF)HumanFibronectin synthesis / releaseELISA / EIABasal
NHDF, hyaluronic acid synthesis/release (basal)

NHDF, hyaluronic acid synthesis/release (basal)

Type of assayGAG synthesis
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointHyaluronic acid synthesis / release
NHDF-0008ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsGAG synthesisDermal fibroblasts (NHDF)HumanHyaluronic acid synthesis / releaseELISA / EIABasal
NHDF, total GAG synthesis (basal)

NHDF, total GAG synthesis (basal)

Type of assayGAG synthesis
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointGlycosaminoglycans (GAGs, total)
NHDF-0009ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsGAG synthesisDermal fibroblasts (NHDF)HumanGlycosaminoglycans (GAGs, total)[3H]-glucosamine incorporationBasal
NHDF, sulfated GAG synthesis (basal)

NHDF, sulfated GAG synthesis (basal)

Type of assayGAG synthesis
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointSulfated glycosaminoglycans (sulfated GAGs)
NHDF-0010ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsGAG synthesisDermal fibroblasts (NHDF)HumanSulfated glycosaminoglycans (sulfated GAGs)Sulfur-35 (35S) incorporationBasal
NHDF, ECM gene expression (basal)

NHDF, ECM gene expression (basal)

Type of assayGene expression
Biological modelDermal fibroblasts (NHDF)
SpeciesHuman
EndpointECM components mRNA, mQPA-NHDF-16, mQPA-NHDF-32, mQPA-NHDF-64
NHDF-0011ECM synthesis, Wound healing, trauma & agressions, Wound healing, trauma & aggressionsGene expressionDermal fibroblasts (NHDF)HumanECM components mRNA, mQPA-NHDF-16, mQPA-NHDF-32, mQPA-NHDF-64RT-qPCR, qPCRarray (standard or customized)Basal
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