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You are viewing records 1-20 out of 38 total records on 2 pages
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Plus d'options Reference Physio-pathology Type of assay Biological model Species Endpoint Method Stimulating factor / inducer
B16, stimulation of melanin synthesis (basal, pro-pigmenting agents)

B16, stimulation of melanin synthesis (basal, pro-pigmenting agents)

Type of assayMelanin synthesis
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointMelanin content
B16-0001Melanogenesis, Pigmentation disordersMelanin synthesisB16 melanoma cell lineMouseMelanin contentPhotometryBasal
B16, inhibition of melanin synthesis (MSH-induced, whitening agents)

B16, inhibition of melanin synthesis (MSH-induced, whitening agents)

Type of assayMelanin synthesis
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointMelanin content
B16-0002Melanogenesis, Pigmentation disordersMelanin synthesisB16 melanoma cell lineMouseMelanin contentPhotometryNDP-MSH
B16, tyrosinase expression (basal)

B16, tyrosinase expression (basal)

Type of assayMelanogenic proteins
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointTyrosinase immunolabeling
B16-0010Melanogenesis, Pigmentation disordersMelanogenic proteinsB16 melanoma cell lineMouseTyrosinase immunolabelingImmunofluorescenceBasal
B16, tyrosinase expression (MSH stimulation)

B16, tyrosinase expression (MSH stimulation)

Type of assayMelanogenic proteins
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointTyrosinase immunolabeling
B16-0011Melanogenesis, Pigmentation disordersMelanogenic proteinsB16 melanoma cell lineMouseTyrosinase immunolabelingImmunofluorescenceNDP-MSH
B16, TRP-1 expression (basal)

B16, TRP-1 expression (basal)

Type of assayMelanogenic proteins
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointTRP-1 immunolabeling
B16-0012Melanogenesis, Pigmentation disordersMelanogenic proteinsB16 melanoma cell lineMouseTRP-1 immunolabelingImmunofluorescenceBasal
B16, TRP-1 expression (MSH stimulation)

B16, TRP-1 expression (MSH stimulation)

Type of assayMelanogenic proteins
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointTRP-1 expression
B16-0013Melanogenesis, Pigmentation disordersMelanogenic proteinsB16 melanoma cell lineMouseTRP-1 expressionImmunofluorescenceNDP-MSH
B16, tyrosinase activity (basal)

B16, tyrosinase activity (basal)

Type of assayMelanogenic proteins
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointTyrosinase activity
B16-0014Melanogenesis, Pigmentation disordersMelanogenic proteinsB16 melanoma cell lineMouseTyrosinase activityPhotometryBasal
B16, pigmentation-related gene expression (basal)

B16, pigmentation-related gene expression (basal)

Type of assayGene expression
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointmRNA: e.g. TYR, TRP1, TRP2, MITF, MC1R,..., mQPA-B16-16, mQPA-B16-64
B16-0016Melanogenesis, Pigmentation disordersGene expressionB16 melanoma cell lineMousemRNA: e.g. TYR, TRP1, TRP2, MITF, MC1R,..., mQPA-B16-16, mQPA-B16-64RT-qPCR, qPCRarray (standard or customized)Basal
B16, pigmentation-related gene expression (MSH stimulation)

B16, pigmentation-related gene expression (MSH stimulation)

Type of assayGene expression
Biological modelB16 melanoma cell line
SpeciesMouse
EndpointmRNA: e.g. TYR, TRP1, TRP2, MITF, MC1R,..., mQPA-B16-16, mQPA-B16-64
B16-0018Melanogenesis, Pigmentation disordersGene expressionB16 melanoma cell lineMousemRNA: e.g. TYR, TRP1, TRP2, MITF, MC1R,..., mQPA-B16-16, mQPA-B16-64RT-qPCR, qPCRarray (standard or customized)NDP-MSH
Tyrosinase inhibition (mushroom enzyme)

Tyrosinase inhibition (mushroom enzyme)

Type of assayTyrosinase inhibition
Biological modelAcellular
Species
EndpointTyrosinase activity
BIOCH-0010Enzyme activity assays, Melanogenesis, Pigmentation disordersTyrosinase inhibitionAcellularTyrosinase activityPhotometry
Tyrosinase inhibition (NHEM extract)

Tyrosinase inhibition (NHEM extract)

Type of assayTyrosinase inhibition
Biological modelAcellular
SpeciesHuman
EndpointTyrosinase activity
BIOCH-0011Enzyme activity assays, Melanogenesis, Pigmentation disordersTyrosinase inhibitionAcellularHumanTyrosinase activityPhotometryBasal
Hair follicle, pigmentation-related gene expression (basal)

Hair follicle, pigmentation-related gene expression (basal)

Type of assayGene expression
Biological modelHair follicle
SpeciesHuman
EndpointmRNA: e.g. TYR, TRP1, MITF, MC1R,..., mQPA-HAIR
FOLL-0009Hair pigmentation, Melanogenesis, Pigmentation disordersGene expressionHair follicleHumanmRNA: e.g. TYR, TRP1, MITF, MC1R,..., mQPA-HAIRRT-qPCR, qPCRarray (standard or customized)Basal
NHEK + NHEM, stimulation of melanin synthesis (Basal, pro-pigmenting agents)

NHEK + NHEM, stimulation of melanin synthesis (Basal, pro-pigmenting agents)

Type of assayMelanin synthesis
Biological modelKeratinocytes + Melanocytes, coculture
SpeciesHuman
EndpointMelanin content
KM-0001Melanogenesis, Pigmentation disordersMelanin synthesisKeratinocytes + Melanocytes, cocultureHumanMelanin contentPhotometryBasal
NHEK + NHEM, tyrosinase expression (basal)

NHEK + NHEM, tyrosinase expression (basal)

Type of assayMelanogenic proteins
Biological modelKeratinocytes + Melanocytes, coculture
SpeciesHuman
EndpointTyrosinase immunolabeling
KM-0003Melanogenesis, Pigmentation disordersMelanogenic proteinsKeratinocytes + Melanocytes, cocultureHumanTyrosinase immunolabelingImmunofluorescenceBasal
NHEK + NHEM, TRP-1 expression (basal)

NHEK + NHEM, TRP-1 expression (basal)

Type of assayMelanogenic proteins
Biological modelKeratinocytes + Melanocytes, coculture
SpeciesHuman
EndpointTRP-1 immunolabeling
KM-0005Melanogenesis, Pigmentation disordersMelanogenic proteinsKeratinocytes + Melanocytes, cocultureHumanTRP-1 immunolabelingImmunofluorescenceBasal
NHEK + NHEM, melanocyte dendricity (basal)

NHEK + NHEM, melanocyte dendricity (basal)

Type of assayMelanocyte dendricity
Biological modelKeratinocytes + Melanocytes, coculture
SpeciesHuman
EndpointTRP-1 immunolabeling
KM-0011Melanin transfer, Pigmentation disordersMelanocyte dendricityKeratinocytes + Melanocytes, cocultureHumanTRP-1 immunolabelingImmunofluorescenceBasal
NHEK + NHEM, inhibition of melanin synthesis (MSH stimulation, depigmenting molecules)

NHEK + NHEM, inhibition of melanin synthesis (MSH stimulation, depigmenting molecules)

Type of assayMelanin synthesis
Biological modelKeratinocytes + Melanocytes, coculture
SpeciesHuman
EndpointMelanin content
KM-0015Melanogenesis, Pigmentation disordersMelanin synthesisKeratinocytes + Melanocytes, cocultureHumanMelanin contentPhotometryNDP-MSH
NHEK + NHEM, melanocyte dendricity (IBMX stimulation)

NHEK + NHEM, melanocyte dendricity (IBMX stimulation)

Type of assayMelanocyte dendricity
Biological modelKeratinocytes + Melanocytes, coculture
SpeciesHuman
EndpointTRP-1 immunolabeling
KM-0016Melanin transfer, Pigmentation disordersMelanocyte dendricityKeratinocytes + Melanocytes, cocultureHumanTRP-1 immunolabelingImmunofluorescenceIBMX
NHEK, phagocytic activity (basal)

NHEK, phagocytic activity (basal)

Type of assayPhagocytosis
Biological modelEpidermal keratinocytes (NHEK)
SpeciesHuman
EndpointFluorosphere phagocytosis
NHEK-0089Melanin transfer, Pigmentation disordersPhagocytosisEpidermal keratinocytes (NHEK)HumanFluorosphere phagocytosisFlow cytometryBasal
NHEM, stimulation of melanin synthesis (Basal, pro-pigmenting agents)

NHEM, stimulation of melanin synthesis (Basal, pro-pigmenting agents)

Type of assayMelanin synthesis
Biological modelEpidermal melanocytes (NHEM)
SpeciesHuman
EndpointMelanin content
NHEM-0001Melanogenesis, Pigmentation disordersMelanin synthesisEpidermal melanocytes (NHEM)HumanMelanin contentPhotometryBasal
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