Mast cells degranulation, histamine release (compound 48/80 stimulation)| Type of assay | Degranulation | | Biological model | Mast cells (peritoneal) | | Species | Rat | | Endpoint | Histamine release |
| MAST-0001 | Sensitive skin, Basophils/Mast cells, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Mast cells: allergy, inflammation, B cell help, Peripheral inflammation, sensitivity, pain, itching | Degranulation | Mast cells (peritoneal) | Rat | Histamine release | ELISA / EIA | CP48/80 | |
Motoneurons + striated muscle cells, contraction frequency (basal)| Type of assay | Muscle contraction | | Biological model | Motoneurons + Striated muscle cells, coculture | | Species | Rat / Human | | Endpoint | Contraction frequency |
| NMOT-0003 | Relaxing effects (Botox-like, etc.), Neuromuscular diseases | Muscle contraction | Motoneurons + Striated muscle cells, coculture | Rat / Human | Contraction frequency | Time-lapse microscopy | Basal | |
Sensory neurons, calcium mobilization (histamine stimulation)| Type of assay | Signal transduction | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | Calcium mobilization |
| NS-0002 | Sensitive skin, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Signal transduction | Sensory neurons | Rat | Calcium mobilization | Time-lapse microscopy | Histamine | |
Sensory neurons, calcium mobilization (capsaicin stimulation)| Type of assay | Signal transduction | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | Calcium mobilization |
| NS-0003 | Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Signal transduction | Sensory neurons | Rat | Calcium mobilization | Time-lapse microscopy | Capsaicin | |
Sensory neurons, CGRP release (capsaicin stimulation)| Type of assay | Neuromediators | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | CGRP release |
| NS-0004 | Sensitive skin, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons | Rat | CGRP release | ELISA / EIA | Capsaicin | |
Sensory neurons, substance P release (capsaicin stimulation)| Type of assay | Neuromediators | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | Substance P release |
| NS-0005 | Sensitive skin, Atopic dermatitis, Pruritus, itching, Atopic dermatitis, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons | Rat | Substance P release | ELISA / EIA | Capsaicin | |
Sensory neurons, CGRP release (basal)| Type of assay | Neuromediators | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | CGRP release |
| NS-0009 | Sensitive skin, Skin sensitization, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons | Rat | CGRP release | ELISA / EIA | Basal | |
Sensory neurons, delta opioid receptor expression (basal)| Type of assay | Neuromediators | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | Delta opioid receptor expression |
| NS-0010 | Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons | Rat | Delta opioid receptor expression | Immunofluorescence | Basal | |
Sensory neurons, substance P release (Basal)| Type of assay | Neuromediators | | Biological model | Sensory neurons | | Species | Rat | | Endpoint | Substance P release |
| NS-0011 | Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons | Rat | Substance P release | ELISA / EIA | Basal | |
Sensory neurons+NHEK, CGRP release (capsaicin stimulation)| Type of assay | Neuromediators | | Biological model | Sensory neurons + Keratinocytes, coculture | | Species | Rat / Human | | Endpoint | CGRP release |
| NSK-0001 | Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons + Keratinocytes, coculture | Rat / Human | CGRP release | ELISA / EIA | Capsaicin | |
Sensory neurons+NHEK, substance P release (capsaicin stimulation)| Type of assay | Neuromediators | | Biological model | Sensory neurons + Keratinocytes, coculture | | Species | Rat / Human | | Endpoint | Substance P release |
| NSK-0002 | Sensitive skin, Pruritus, itching, Pruritus, itching, Peripheral inflammation, sensitivity, pain, itching | Neuromediators | Sensory neurons + Keratinocytes, coculture | Rat / Human | Substance P release | ELISA / EIA | Capsaicin | |
