Ensembles des articles, publications et posters de QIMA Life Sciences traitant de la pigmentation et des modèles in vitro et ex vivo développés.

Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo

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Loss of melanocytes is the pathological hallmark of vitiligo.

Cystinosin is a melanosomal protein that regulates melanin synthesis

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In vitro studies showed that cystinosin was located at melanosomes. CTNS silencing led to a 75% reduction of melanin synthesis that was caused by a degradation of tyrosinase by lysosomal proteases. Our results objectify the pigmentation defect in patients with cystinosis. We also identify the role of CTNS in melanogenesis and add a new gene to the list of the genes involved in the control of skin and hair pigmentation.