Safety/Toxicology

Safety assessment of compounds is an important criterion before expensive preclinical and clinical studies. In order to predict early cytotoxicity or specific cellular impacts, BIOalternatives provides services for toxicity and safety profiling in a wide range of normal cells or cell lines (blood and immune cells, neurons, epithelial and mesenchymal cells).

Samples

Your compounds:

Chemical entities,
Crude extracts,
Actives, etc.

in individual tubes (powder or liquid) or in 96-well plates.

Samples Preparation

Compound preparation:

Solubility testing,
Master plate preparation (screening),
Storage.

Examples of Validated Assays

Standard cytotoxicity assays

Cytotoxicity profile using HCS technology:

5 end-points in a single assay.

Phototoxicity assays:

3T3/NRU assay,
RHE/NRU assay.

Apoptosis assays

Irritation, inflammation & sensitization assays, e.g.:

Cytokine/chimiokine release (IL-1a, IL-8, TSLP...),
Arachidonic mediator release,
Histamine & neuropeptide release,
Barrier function,
Activation marker expression (CD86...).

Biomarker profiling:

Full trascriptome,
qPCR arrays.

New assay design/validation on request.

Information & Reporting

Laboratory processes, data and reporting managed through in-house Ba®LIMS.

Standard Reporting or customized reports according to client's specifications.

BIOalternatives, 1 bis rue des plantes 86160 GENCAY - France Tel: +33 (0)549.36.11.37
Fax: +33 (0)549.53.10.29