Dendritic & Langerhans cells: inflammation, innate & adaptative immunity
CD34LC-0001 : CD34-LC, cytokine release (PGN stimulation)
- Cell Model :
CD34+ progenitor-derived Langerhans cells
- Parameter/biomarker/endpoint :
TNF- alpha release (low)
- Method :
ELISA
- Stimulating factor/inducer :
PGN
- Reference compound :
Dexamethasone
IL-6
CD34LC-0002 : CD34-LC, cytokine release (poly (I:C) stimulation)
- Cell Model :
CD34+ progenitor-derived Langerhans cells
- Parameter/biomarker/endpoint :
TNF- alpha release (low)
- Method :
ELISA
- Stimulating factor/inducer :
Poly (I:C)
- Reference compound :
Dexamethasone
IL-23
CD34LC-0003 : CD34-LC, cytokine release (CpG stimulation)
- Cell Model :
CD34+ progenitor-derived Langerhans cells
- Parameter/biomarker/endpoint :
TNF- alpha release (low)
- Method :
ELISA
- Stimulating factor/inducer :
CpG-ODN
- Reference compound :
Dexamethasone
IL-6
MODC-0001 : Mo-DC, cytokine release (LPS stimulation)
- Cell Model :
Monocyte-derived dendritic cells
- Parameter/biomarker/endpoint :
TNF- alpha release
- Method :
ELISA
- Stimulating factor/inducer :
LPS
- Reference compound :
Dexamethasone
IL-6
MODC-0002 : Mo-DC, cytokine release (PGN stimulation)
- Cell Model :
Monocyte-derived dendritic cells
- Parameter/biomarker/endpoint :
TNF- alpha release
- Method :
ELISA
- Stimulating factor/inducer :
PGN
- Reference compound :
Dexamethasone
IL-6
MODC-0003 : Mo-DC, cytokine release (R848 stimulation)
- Cell Model :
Monocyte-derived dendritic cells
- Parameter/biomarker/endpoint :
TNF- alpha release
- Method :
ELISA
- Stimulating factor/inducer :
R848
- Reference compound :
Dexamethasone
IL-6
SKIN-0003 : Skin samples, DC/LC immunolabeling
- Cell Model :
Skin samples
- Parameter/biomarker/endpoint :
CD1a immunolabeling
- Method :
Immunofluorescence
CD207/CD209 immunolabeling
