T lymphocytes: anti-inflammatory effects/immunosuppression - cell-mediated and humoral immunity modulation
CD4TL-0001 : CD4+ T cells, cytokine release (anti-CD3/anti-CD28 stimulation)
- Cell Model :
CD4+ T cells
- Parameter/biomarker/endpoint :
IFN- gamma release
- Method :
ELISA
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
Cyclosporin A
TNF-alpha
IFN-gamma
CD4TL-0002 : CD4+ T cells, multiplex cytokine release (anti-CD3/anti-CD28 stimulation)
- Cell Model :
CD4+ T cells
- Parameter/biomarker/endpoint :
Cytokines, multiplex
- Method :
Flow cytometry (CBA)
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
Cyclosporin A
CD4TL-0005 : CD4+ T cells, cytokine release (anti-CD3/anti-CD28 stimulation)
- Cell Model :
CD4+ T cells
- Parameter/biomarker/endpoint :
IL-4 release
- Method :
ELISA
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
Cyclosporin A
IL-4
CD4TL-0007 : CD4+ T cells, cytokine release (anti-CD3/anti-CD28 stimulation)
- Cell Model :
CD4+ T cells
- Parameter/biomarker/endpoint :
IL-17 release
- Method :
ELISA
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
Cyclosporin A
IL-17
CD4TL-0009 : CD4+ T cells, cytokine release (anti-CD3/anti-CD28 stimulation)
- Cell Model :
CD4+ T cells
- Parameter/biomarker/endpoint :
IL-10 release
- Method :
ELISA
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
Cyclosporin A
IL-10
CD4TL-0016 : CD4+ T cells, IL-10 immunosuppression (anti-CD3/anti-CD28 stimulation)
- Cell Model :
CD4+ T cells
- Parameter/biomarker/endpoint :
IL-2 release
- Method :
ELISA
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
IL-10
IL-2
PBMC-0001 : T cell proliferation (PHA stimulation)
- Cell Model :
Peripheral blood mononuclear cells
- Parameter/biomarker/endpoint :
Proliferation
- Method :
[3H]-thymidine incorporation
- Stimulating factor/inducer :
PHA
- Reference compound :
Dexamethasone
PBMC proliferation
PBMC-0002 : T cells, CD25 expression (PHA stimulation)
- Cell Model :
Peripheral blood mononuclear cells
- Parameter/biomarker/endpoint :
CD25 expression
- Method :
Flow cytometry
- Stimulating factor/inducer :
PHA
- Reference compound :
Dexamethasone
PBMC CD25 expression
PBMC-0008 : T cells, cytokine release (anti-CD3/anti-CD28 stimulation)
- Cell Model :
Peripheral blood mononuclear cells
- Parameter/biomarker/endpoint :
TNF- alpha release
- Method :
ELISA
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
Cyclosporin A
TNF-alpha
IFN-gamma
PBMC-0009 : T cells, cytokine release (anti-CD3/anti-CD28 stimulation)
- Cell Model :
Peripheral blood mononuclear cells
- Parameter/biomarker/endpoint :
IL-4 release
- Method :
ELISA
- Stimulating factor/inducer :
Anti-CD3/anti-CD28
- Reference compound :
Cyclosporin A
IL-4
