In vitro & ex vivo models

in vitro models, cell librairies and related services

 

in vitro models, a source of innovation for drugs of tomorrow...

Wide range of relevant in vitro / ex vivo models:

  • Primary cell or secondary cultures,
  • Immortalized / transfected cell lines,
  • Stem cells, cell progenitors,
  • Reconstructed tissues,
  • ex vivo cultures.

Most of our models are:

  • In-house developed,
  • Human source,
  • Multiple donors
  • Healthy or pathological one.

Currently models:

Human blood-derived cells

  • Whole Blood
  • PBMCs
  • CD4+ & other subtypes of T cells
  • T cells from healthy or pathologic tissue
  • CD19+ B cells
  • CD14+ monocytes
  • CD34+ LC
  • Mo-DC
  • Granulocytes

Rodent primary leukocytes

  • Thymocytes
  • Splenocytes
  • Mast cells
  • Microglia

Human endothelial cells

  • Dermal microvascular endothelial cells
  • Umbilical vascular cells

Human mesenchymal cells

  • Stem cells
  • Dermal fibroblasts
  • Papilla fibroblasts
  • Preadipocytes
  • Adipocytes
  • Aortic smooth muscle
  • Skeletal muscle
  • Osteoblasts
  • Chondrocytes

Human epithelial cells

  • Keratinocytes
  • Nasal cells
  • Airway cells
  • Prostate cells

Pigment cells

  • Melanocytes & co-cultures

Human reconstructed tissues

  • Epidermis
  • Sebocytes 3D
  • Full thickness skin
  • Intestinal barrier
  • Chondrospheres

Ex vivo explants 

  • Normal skin
  • Hair follicles
  • Spinal cord (rat)
  • Dorsal root ganglia (rat sensory neurons)

Rodent neuronal cells

  • Cortical neurons
  • Dopaminergic neurons
  • Hippocampal neurons
  • Sensory neurons
  • Motoneurons

Rodent Glial cells

  • Astrocytes
  • Oligodendrocytes
  • Oligodendrocyte precursor cells
  • Microglia
  • Schwann cells

Cell lines or clones

  • U937
  • HL-60
  • THP-1
  • B16
  • 3T3-L1
  • SEBO662 
  • K562
  • KU812
  • Jurkat
  • RAW 264.7
  • A431
  • Caco-2
  • HT-29
  • MCF-7
  • 22Rv1
  • G-361
  • VA-ES-BJ
  • PC12
  • SH-SY5Y
  • HFL1
  • HL-1
  • 3T3
  • SIRC
  • MC3T3-E1
  • NCTC L-929
  • RWEP-1
  • ...
 

Many mixed culture and co-culture models are also available.

 

 

Cell culture services

  • in vitro assays using models (cells or tissue samples) provided by client,

  • cell isolation, purification, cloning, sorting,

  • transfection, target silencing/ overexpression,

  • phenotypic and functional characterization (transcriptome, proteome),

  • tissue engineering.

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    BIOalternatives, 1 bis rue des plantes 86160 GENCAY - France Tel: +33 (0)549.36.11.37
    Fax: +33 (0)549.53.10.29
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