Biological models

Relevant models, a source of innovation for tomorrow's drugs...

 

Wide range of relevant in vitro / ex vivo models:

  • Primary cell or secondary cultures,
  • Immortalized / transfected cell lines,
  • Stem cells,
  • Reconstructed tissues,
  • ex vivo cultures.

Most of our models are:

  • In-house developed,
  • Human source,
  • Healthy or pathological one.
 


neuron sensitive incell Normal skeletal muscle cells Nerf muscle Miscellaneous models Dorsal Root Ganglion explants adipocytes HSL skin inflammation human skin HSE 01 growth hair progeniteurs neurofilament human melanocytes giemsa
 
 

Currently models:

Human blood-derived cells

  • Whole Blood
  • PBMCs
  • CD4+ & other subtypes of T cells
  • T cells from healthy or pathologic tissue
  • CD19+ B cells
  • CD14+ monocytes
  • CD34+ LC
  • Mo-DC
  • Granulocytes

Rodent primary leukocytes

  • Thymocytes
  • Splenocytes
  • Mast cells
  • Microglia

Human endothelial cells

  • Dermal microvascular endothelial cells
  • Umbilical vascular cells
 

Human mesenchymal cells

  • Stem cells
  • Dermal fibroblasts
  • Papilla fibroblasts
  • Preadipocytes
  • Adipocytes
  • Aortic smooth muscle
  • Skeletal muscle
  • Osteoblasts
  • Chondrocytes

Human epithelial cells

  • Keratinocytes
  • Nasal cells
  • Airway cells
  • Prostate cells

Pigment cells

  • Melanocytes & cocultures
 
 

Human reconstructed tissues

Explants ex vivo

  • Normal skin
  • Hair follicles
  • Spinal cord (rat)
  • Dorsal root ganglia (rat sensory neurons)

Rodent neuronal cells

  • Cortical neurons
  • Dopaminergic neurons
  • Hippocampal neurons
  • Sensory neurons
  • Motoneurons

Rodent Glial cells

  • Astrocytes
  • Oligodendrocytes
  • Oligodendrocyte precursor cells
  • Microglia
  • Schwann cells
 

Cell lines or clones

  • U937
  • HL-60
  • THP-1
  • K562
  • KU812
  • Jurkat
  • RAW 264.7
  • A431
  • Caco-2
  • HT-29
  • MCF-7
  • 22Rv1
  • G-361
  • VA-ES-BJ
  • PC12
  • SH-SY5Y
  • B16
  • HFL1
  • HL-1
  • 3T3
  • 3T3-L1
  • SIRC
  • MC3T3-E1
  • NCTC L-929
  • RWEP-1
  • ...
 
 

Many mixed culture and co-culture models are also available.

Alternatively, BIOalternatives can provide services using cells or tissue samples provided by client itself.

 

News & events

Guilloteau et al

Skin Inflammation...

BIOalternatives' publication: Skin Inflammation...

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psoriasis

Skin inflammation:...

skin inflammation in vitro assays for...

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Adress

BIOalternatives
1 bis rue des plantes
F-86160 GENCAY
France
Tel: +33(0)549.36.11.37
Fax: +33(0)549.53.10.29

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