Peripheral inflammation, sensitivity, pain, itching
MAST-0001 : Mast cells, histamine release (compound 48/80 stimulation)
- Cell Model :
Mast cells (peritoneal)
- Parameter/biomarker/endpoint :
Histamine release
- Method :
ELISA
- Stimulating factor/inducer :
CP48/80
- Reference compound :
Cromoglycate
cp48/80-stimulated
cp48/80-stimulated
NS-0002 : Sensory neurons, calcium mobilization (histamine stimulation)
- Cell Model :
Sensory neurons
- Parameter/biomarker/endpoint :
Calcium mobilization
- Method :
Time-lapse microscopy
- Stimulating factor/inducer :
Histamine
- Reference compound :
Chlorpheniramine
Sensory neurons
Histamine-stimulated
NS-0003 : Sensory neurons, calcium mobilization (capsaicin stimulation)
- Cell Model :
Sensory neurons
- Parameter/biomarker/endpoint :
Calcium mobilization
- Method :
Time-lapse microscopy
- Stimulating factor/inducer :
Capsaicin
- Reference compound :
Capsazepine
Sensory neurons
Capsaicin-stimulated
NS-0004 : Sensory neurons, CGRP release (capsaicin stimulation)
- Cell Model :
Sensory neurons
- Parameter/biomarker/endpoint :
CGRP release
- Method :
ELISA
- Stimulating factor/inducer :
Capsaicin
- Reference compound :
Capsazepine
Sensory neurons
CGRP
NS-0005 : Sensory neurons, substance P release (capsaicin stimulation)
- Cell Model :
Sensory neurons
- Parameter/biomarker/endpoint :
Substance P release
- Method :
ELISA
- Stimulating factor/inducer :
Capsaicin
- Reference compound :
Capsazepine
Sensory neurons
Substance P
NSK-0001 : Sensory neurons+NHEK, CGRP release (capsaicin stimulation)
- Cell Model :
Sensory neurons + keratinocytes
- Parameter/biomarker/endpoint :
CGRP release
- Method :
ELISA
- Stimulating factor/inducer :
Capsaicin
- Reference compound :
Capsazepine
Sensory neurons + keratinocytes
CGRP
NSK-0002 : Sensory neurons+NHEK, substance P release (capsaicin stimulation)
- Cell Model :
Sensory neurons + keratinocytes
- Parameter/biomarker/endpoint :
Substance P release
- Method :
ELISA
- Stimulating factor/inducer :
Capsaicin
- Reference compound :
Capsazepine
Sensory neurons + keratinocytes
