MAST-0001 : Mast cells, histamine release (compound 48/80 stimulation)

  • Cell Model :

    Mast cells (peritoneal)

  • Source :

    Rat

  • Parameter/biomarker/endpoint :

    Histamine release

  • Method :

    ELISA

  • Stimulating factor/inducer :

    CP48/80

  • Reference compound :

    Cromoglycate

Physio-pathology :

  • Mast cells: allergy, inflammation, B cell help
  • Pruritus, itching
  • Peripheral inflammation, sensitivity, pain, itching
  • Sensitive skin

  • Type of assay :

    Degranulation