Demyelinating diseases & multiple sclerosis
NCOD-0001 : Oligodendrocyte + cortical neurons, myelination (basal)
- Cell Model :
Oligodendrocytes + cortical neurons + astrocytes
- Parameter/biomarker/endpoint :
MBP / beta-III tubulin
- Method :
Immunofluorescence
- Stimulating factor/inducer :
Basal
- Reference compound :
bFGF
Oligodendrocytes bis
Oligodendrocytes-Neurons
OPC-0001 : Oligodendrocyte proliferation (basal)
- Cell Model :
Oligodendrocyte precursor cells
- Parameter/biomarker/endpoint :
A2B5 labeling
- Method :
Immunofluorescence
- Stimulating factor/inducer :
Basal
- Reference compound :
PDGF-AA + bFGF
Control
PDGF-AA + bFGF - stimulated
OPC-0002 : Oligodendrocyte differentiation (basal)
- Cell Model :
Oligodendrocyte precursor cells
- Parameter/biomarker/endpoint :
MBP expression
- Method :
Immunofluorescence
- Stimulating factor/inducer :
Basal
- Reference compound :
T3 + CNTF
Control
T3 + CNTF - stimulated
