Hair growth & degeneration
DPF-0001 : DPF, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Dermal papilla fibroblasts
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
FOLL-0002 : Hair follicle growth & degeneration (basal)
- Cell Model :
Hair follicle
- Parameter/biomarker/endpoint :
Morphology until apoptosis
- Method :
Imaging
- Stimulating factor/inducer :
Basal
Normal
Apoptotic
FOLL-0001 : Hair follicle growth (basal)
- Cell Model :
Hair follicle
- Parameter/biomarker/endpoint :
Growth measurement for 7 days
- Method :
Imaging
- Stimulating factor/inducer :
Basal
Day 0
Day 7
FOLL-0004 : Hair follicle, gene expression (basal)
- Cell Model :
Hair follicle
- Parameter/biomarker/endpoint :
Selection of genes of interest
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
FOLL-0003 : Hair follicle, protein expression (basal)
- Cell Model :
Hair follicle
- Parameter/biomarker/endpoint :
Fibronectin expression
- Method :
Immunofluorescence
- Stimulating factor/inducer :
Basal
Fibronectin (Epifluorescence)
Fibronectin (Confocal microscopy)
FOLL-0006 : Hair follicle, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Hair follicle
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
NHDF-0050 : NHDF, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
NHEK-0124 : NHEK, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
EPIBA-0052 : RHE, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Reconstructed epidermis (EPI-Ba)
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
