Epidermal cohesion, cell adhesion & cell junctions
EPIBA-0038 : RHE, desmosomal, tight & other cell-cell adhesion proteins (basal)
- Cell Model :
Reconstructed epidermis (EPI-Ba)
- Parameter/biomarker/endpoint :
Expression of e.g. desmosome proteins, E-cadherin, claudins, occludin …
- Method :
Immunofluorescence or IHC
- Stimulating factor/inducer :
Basal
Desmoglein-3
EPIBA-0039 : RHE, mRNA for epidermal adhesion proteins (basal)
- Cell Model :
Reconstructed epidermis (EPI-Ba)
- Parameter/biomarker/endpoint :
mRNA: e.g. DSG1, DSP, CDH1, CLDN1, OCLN …
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
- Reference compound :
Depending on the selected marker
Retinoic acid
NHEK-0075 : NHEK, desmosomal, tight & other cell-cell adhesion proteins (basal)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
Expression of e.g. desmosome proteins, E-cadherin, claudins, occludin …
- Method :
Immunofluorescence
- Stimulating factor/inducer :
Basal
- Reference compound :
Depending on the selected marker
Ctrl
Calcium
NHEK-0076 : NHEK, mRNA for epidermal adhesion proteins (basal)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
mRNA: e.g. DSG1, DSP, CDH1, CLDN1, OCLN …
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
- Reference compound :
Depending on the selected marker
Calcium
SKIN-0018 : Skin maintained ex vivo, desmosomal, tight & other cell-cell adhesion proteins (basal)
- Cell Model :
Skin (ex vivo)
- Parameter/biomarker/endpoint :
Expression of e.g. desmosome proteins, E-cadherin, claudins, occludin …
- Method :
Immunofluorescence or IHC
- Stimulating factor/inducer :
Basal
Claudin-1
SKIN-0019 : Skin maintained ex vivo, mRNA for epidermal adhesion proteins (basal)
- Cell Model :
Skin (ex vivo)
- Parameter/biomarker/endpoint :
mRNA: e.g. DSG1, DSP, CDH1, CLDN1, OCLN …
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
- Reference compound :
Depending on the selected marker
