Epidermal cohesion, dermo-epidermal junction
EPIBA-0035 : RHE, dermo-epidermal junction proteins expression (basal)
- Cell Model :
Reconstructed epidermis (EPI-Ba)
- Parameter/biomarker/endpoint :
Collagen IV expression
- Method :
Immunofluorescence or IHC
- Stimulating factor/inducer :
Basal
Laminin V
EPIBA-0036 : RHE, mRNA for dermo-epidermal junction proteins (basal)
- Cell Model :
Reconstructed epidermis (EPI-Ba)
- Parameter/biomarker/endpoint :
mRNA LAMA5
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
- Reference compound :
TGF- beta
TGF-beta
NHEK-0072 : NHEK, dermo-epidermal junction proteins expression (basal)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
mRNA LAMA5
- Method :
Immunofluorescence
- Stimulating factor/inducer :
Basal
- Reference compound :
TGF- beta
Ctrl
TGF-beta
NHEK-0073 : NHEK, mRNA for dermo-epidermal junction proteins (basal)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
mRNA LAMA5
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
- Reference compound :
TGF- beta
TGF-beta
SKIBA-0008 : FTSK, dermo-epidermal junction proteins expression (basal)
- Cell Model :
Full thickness reconstructed skin (SKI-Ba)
- Parameter/biomarker/endpoint :
Collagen IV expression
- Method :
Immunofluorescence or IHC
- Stimulating factor/inducer :
Basal
Laminin V
Laminin V
SKIBA-0009 : FTSK, mRNA for dermo-epidermal junction proteins (basal)
- Cell Model :
Full thickness reconstructed skin (SKI-Ba)
- Parameter/biomarker/endpoint :
mRNA: e.g. LAMC2, COL4A1, COL7A1,…PGs…
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
SKIN-0015 : Skin maintained ex vivo, dermo-epidermal junction proteins expression (basal)
- Cell Model :
Skin (ex vivo)
- Parameter/biomarker/endpoint :
Collagen IV expression
- Method :
Immunofluorescence or IHC
- Stimulating factor/inducer :
Basal
Laminin V
SKIN-0016 : Skin maintained ex vivo, mRNA for dermo-epidermal junction proteins (basal)
- Cell Model :
Skin (ex vivo)
- Parameter/biomarker/endpoint :
mRNA LAMA5
- Method :
RT-qPCR
- Stimulating factor/inducer :
Basal
