Dermal fibrosis
NHDF-0021 : NHDF, mTOR pathway activation (basal)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
rpS6 phosphorylation
- Method :
Western blot
- Stimulating factor/inducer :
Basal
- Reference compound :
FCS
Western blot
Image analysis
NHDF-0033 : NHDF, proliferation (TGF- beta stimulation)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
Proliferation
- Method :
[3H]-thymidine incorporation
- Stimulating factor/inducer :
TGF- beta
- Reference compound :
Dexamethasone
Proliferation
NHDF-0034 : NHDF, neosynthesis of prolin-rich ECM proteins (TGF- beta stimulation)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
Prolin-rich ECM proteins synthesis
- Method :
[3H]-prolin incorporation
- Stimulating factor/inducer :
TGF- beta
- Reference compound :
Dexamethasone
Intracellular
Deposited
NHDF-0035 : NHDF, myofibroblasts transformation (TGF- beta stimulation)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
alpha-SMA expression
- Method :
Fluorescence / imaging
- Stimulating factor/inducer :
TGF- beta
- Reference compound :
Dexamethasone
Dexamethasone
TGF-beta
NHDF-0051 : NHDF, myofibroblasts transformation (basal)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
alpha-SMA expression
- Method :
Fluorescence / imaging
- Stimulating factor/inducer :
Basal
- Reference compound :
TGF- beta
Control
TGF-beta
NHDF-0061 : NHDF, mTOR pathway activation (basal)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
rpS6 phosphorylation
- Method :
Fluorescence / imaging
- Stimulating factor/inducer :
Basal
- Reference compound :
FCS
Ctrl
FCS
