Acne
EPIBA-0052 : RHE, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Reconstructed epidermis (EPI-Ba)
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
NHDF-0050 : NHDF, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
NHEK-0045 : NHEK, TLR expression (Pam3CSK4 stimulation)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
mRNA TLR2
- Method :
RT-qPCR
- Stimulating factor/inducer :
Pam3CSK4
TLR2
NHEK-0117 : NHEK, TLR expression (IFN- gamma stimulation)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
mRNA TLR2
- Method :
RT-qPCR
- Stimulating factor/inducer :
IFN- gamma
TLR2
NHEK-0124 : NHEK, testosterone metabolism & 5- alpha reductase activity (basal)
- Cell Model :
Epidermal keratinocytes
- Parameter/biomarker/endpoint :
5- alpha reductase activity
- Method :
[14C]-testosterone incorporation
- Stimulating factor/inducer :
Basal
- Reference compound :
Finasteride
Testosterone metabolisation
