UV, solar, sunburn (dermis)
BIOCH-0019 : Caspase 3/7, enzymatic activity
- Cell Model :
Acellular
- Parameter/biomarker/endpoint :
Caspase 3/7 activity
- Method :
Fluorescence
- Stimulating factor/inducer :
Staurosporine
- Reference compound :
Ac-DEVD-CHO
Caspase
Caspase 2
NHDF-0024 : NHDF, caspase 3/7, enzymatic activity (UV stimulation)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
Caspase 3/7 activity
- Method :
Fluorescence
- Stimulating factor/inducer :
UV
Caspase
Caspase 2
NHDF-0033 : NHDF, proliferation (TGF- beta stimulation)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
Proliferation
- Method :
[3H]-thymidine incorporation
- Stimulating factor/inducer :
TGF- beta
- Reference compound :
Dexamethasone
Proliferation
NHDF-0034 : NHDF, neosynthesis of prolin-rich ECM proteins (TGF- beta stimulation)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
Prolin-rich ECM proteins synthesis
- Method :
[3H]-prolin incorporation
- Stimulating factor/inducer :
TGF- beta
- Reference compound :
Dexamethasone
Intracellular
Deposited
NHDF-0035 : NHDF, myofibroblasts transformation (TGF- beta stimulation)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
alpha-SMA expression
- Method :
Fluorescence / imaging
- Stimulating factor/inducer :
TGF- beta
- Reference compound :
Dexamethasone
Dexamethasone
TGF-beta
NHDF-0051 : NHDF, myofibroblasts transformation (basal)
- Cell Model :
Dermal fibroblasts
- Parameter/biomarker/endpoint :
alpha-SMA expression
- Method :
Fluorescence / imaging
- Stimulating factor/inducer :
Basal
- Reference compound :
TGF- beta
Control
TGF-beta
