Alternative (non-animal) methods for cosmetic testing: current status and future prospects – Acute toxicity

Alternatives to Laboratory Animals, 33 (S1) Chapter 3.1, Acute Toxicity: 27-34

GRIBALDO L., GENNARI A., BLACKBURN K., CLEMEDSON C., DEGUERCY A., MENEGUZ A., PFALLER W. and RUHDEL I. (2005)

ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, Ispra, (VA), Italy.
Procter & Gamble, Miami Valley Laboratories, Ross, OH, USA.
Expertrådet, Sundbyberg, Sweden.
Laboratory of Pharmacology, Istituto Superiore di Sanita’, Roma, Italy.
Bioalternatives, Gençay, France.
University of Innsbruck, Innsbruck, Austria.
German Animal Welfare Federation, Neubiberg, Germany.

Abstract

From the regulatory point of view, the main objective of acute toxicity testing is basically to classify chemicals according to their intrinsic toxicity as required by the EEC directive on the classification, packaging, and labelling of dangerous substances (Council Directive 67/548/EEC and subsequent amendments). This requirement aims to protect public health by regulating exposure to potentially dangerous materials.
The classification of chemicals is done on the basis of the medium lethal dose (LD50) value, defined as « the statistically derived single dose of a substance that can be expected to cause death in 50% of the animals in an experimental group ».

© 2005 L. Gribaldo et al.

KEYWORDS: Acute toxicity; Cosmetic testing; Alternative methods

Check out Bioalternatives’ updates and experience new testing ideas

  • Bioassays, models and services
  • Posts and publications
  • Events

Related Posts or publications

New Biological Activities of Lythrum salicaria L. The perennial and widespread herb Lythrum salicaria L., also called purple loosestrife, is a plant that is traditionally used in European medicine.
Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract Sebocytes lipid production are stimulated by pollutants. Ame acts by protecting epidermal cells, human sebocytes and skin from urban dust.
Acné vulgaris : Physiopathologie et mécanismes cellulaires L’acné vulgaris est une pathologie inflammatoire chronique cutanée localisée au niveau du follicule pilo-sébacé. Elle apparaît suite à une surproduction de sébum liée à des dysfonctionnements d’origine hormonale (androgène), environnementale (polluti...
La glande sébacée : Physiologie et fonctions La glande sébacée est un organe localisé au niveau du derme. Elle est responsable de la synthèse et de la sécrétion du sébum qui entre dans la composition du film hydrolipidique. Le rôle du sébum est de protéger la peau des agressions extérieures et ...
Le cheveu: follicule, structures associées et croissance Le follicule pileux est une annexe de la peau qui a la capacité de se renouveler de manière parfaitement autonome, cyclique et asynchrone. L'analyse histologique de l'unité pilo-sébacée révèle une organisation en deux compartiments: le compartiment d...