https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/SEPPIC-Image-à-la-une.jpg 640 1140 Linhda Coulevard https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Linhda Coulevard2017-11-29 10:57:192017-11-29 10:57:58Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract
Sebocytes lipid production are stimulated by pollutants. Ame acts by protecting epidermal cells, human sebocytes and skin from urban dust.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/Sébocytes-image-à-la-une.jpg 368 701 Linhda Coulevard https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Linhda Coulevard2017-11-28 09:24:342017-12-18 16:01:19La glande sébacée : Physiologie et fonctions
La glande sébacée est un organe localisé au niveau du derme. Elle est responsable de la synthèse et de la sécrétion du sébum qui entre dans la composition du film hydrolipidique. Le rôle du sébum est de protéger la peau des agressions extérieures et de la déshydratation. Le sébum permet également d’entretenir la souplesse de la peau et des cheveux.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/04/structure-cheveu-Image-à-la-une.jpg 368 655 Linhda Coulevard https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Linhda Coulevard2017-06-07 10:27:462017-10-27 14:27:42Le cheveu: follicule, structures associées et croissance
Le follicule pileux est une annexe de la peau qui a la capacité de se renouveler de manière parfaitement autonome, cyclique et asynchrone. L'analyse histologique de l'unité pilo-sébacée révèle une organisation en deux compartiments: le compartiment d'origine épithélial et le compartiment d'origine mésenchymale.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/03/YR-Image-à-la-une.jpg 368 655 Linhda Coulevard https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Linhda Coulevard2017-03-24 12:03:322017-03-27 09:34:33New biological effects of Aphloïol
In the present study, we identified new properties of Aphloïol (syn. mangiferin) in improving skin barrier function, especially by promoting keratinocyte differentiation, synthesis of transmembrane glycoprotein and lipid neosynthesis.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/03/Silab-Image-à-la-une.jpg 350 623 Linhda Coulevard https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Linhda Coulevard2017-03-21 18:10:582017-03-23 12:14:32in vitro modeling of skin photoaging: development of evaluation tools for cosmetics
Development of in vitro models skin for better understand the modifications during photo-aging induced by repetitive UV exposure.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/12/Epiderme-reconstruit-passage-2-figure-1A-1.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2016-12-21 16:21:562016-12-29 11:57:19Development of a new model of reconstructed aged skin useful to study Antiageing effects of cosmetic compounds
The development of new anti-aging products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin aging. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2015-04-09 15:47:492016-12-29 11:58:19Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Cystinosin-is-a-melanosomal-protein.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2012-05-14 09:05:322016-09-29 13:06:33Cystinosin is a melanosomal protein that regulates melanin synthesis
In vitro studies showed that cystinosin was located at melanosomes. CTNS silencing led to a 75% reduction of melanin synthesis that was caused by a degradation of tyrosinase by lysosomal proteases. Our results objectify the pigmentation defect in patients with cystinosis. We also identify the role of CTNS in melanogenesis and add a new gene to the list of the genes involved in the control of skin and hair pigmentation.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2012-01-24 10:17:152016-12-29 11:58:26Immortalized sebocytes SEB0662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Effect-of-C-xyloside.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2011-03-24 10:58:512016-09-29 13:08:32Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study
These data suggest that topical C-xyloside application in vivo may be efficient in inducing a better dermal-epidermal cohesion when such a junction is deficient, as is the case in photo-aged or chronologically aged skin. Moreover, a statistically significant increase in CD44 expression was noted in the epidermis of C-xyloside-treated compared to the placebo treated skin areas.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Lipolytic-effect-of-a-polyphenolic-citrus-dry-extract.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2008-07-09 14:18:052016-09-29 13:16:01Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-Phosphodiesterase (PDE)
The present study investigated the lipolytic (break of fat stored) effect of a citrus-based polyphenolic dietary supplement (SINETROL) at human adipocytes (ex vivo), body fat (clinical) and biochemical levels (inhibition of phosphodiesterase).
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Tensin1.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2008-06-04 16:13:102016-09-29 13:16:34Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction
tensin1 plays an important role in cell-matrix interaction and that a reduced expression might contribute to the dermal alterations observed during skin ageing
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_UV-induced-effects.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2005-05-30 10:47:442016-09-29 13:23:36Alternative (non-animal) methods for cosmetic testing: current status and future prospects - UV-induced effects
cosmetic ingredients and mixtures of ingredients absorbing UV light (in particular UV filter chemicals used, for example, to ensure the light stability of cosmetics or used in sun protection products) should be tested for acute phototoxic and photogenotoxic potential.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Acute-toxicity.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2005-05-30 10:22:572016-09-29 13:24:13Alternative (non-animal) methods for cosmetic testing: current status and future prospects - Acute toxicity
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Comparison-of-gene-expression-profiles.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2002-02-10 11:25:232016-09-29 13:28:05Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis
In order to validate a model for predictive screening of dermatological drugs, we used a customized cDNA macro-array system containing 475 skin-related genes to analyze the gene expression patterns in human keratinocytes from different origins.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Development-of-a-highly-in-vitro-phototoxicity-assay.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2000-12-15 13:01:422016-09-29 13:28:43Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis