The development of three-dimensional models of reconstituted mouse epidermis (RME) has been hampered by the difficulty to maintain murine primary keratinocyte cultures and to achieve a complete epidermal stratification. In this study, a new protocol is proposed for the rapid and convenient generation of RME,
https://www.bioalternatives.com/wp-content/uploads/2017/08/Mouse-epidermis.png368655Linhda Coulevardhttps://www.bioalternatives.com/wp-content/uploads/2018/10/Logo-300x87.pngLinhda Coulevard2017-06-26 09:52:152018-10-24 21:52:57Development of a new model of reconstituted mouse epidermis and characterization of its response to proinflammatory cytokines
Development of in vitro models skin for better understand the modifications during photo-aging induced by repetitive UV exposure.
https://www.bioalternatives.com/wp-content/uploads/2017/03/Silab-Fig-2-2017-03-21.jpg242635Linhda Coulevardhttps://www.bioalternatives.com/wp-content/uploads/2018/10/Logo-300x87.pngLinhda Coulevard2017-03-21 18:10:582018-10-31 10:43:25in vitro modeling of skin photoaging: development of evaluation tools for cosmetics
The development of new anti-ageing products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin ageing. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.
https://www.bioalternatives.com/wp-content/uploads/2016/12/Epiderme-reconstruit-passage-2-figure-1A-1.jpg368655Guillaumehttps://www.bioalternatives.com/wp-content/uploads/2018/10/Logo-300x87.pngGuillaume2016-12-21 16:21:562018-10-24 21:54:20Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds
SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg368655Guillaumehttps://www.bioalternatives.com/wp-content/uploads/2018/10/Logo-300x87.pngGuillaume2012-01-24 10:17:152018-10-24 22:03:29Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells' capability of constructing a pluristratified epidermis.
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Human-embryonic-stem-cell-derivatives.jpg368655Guillaumehttps://www.bioalternatives.com/wp-content/uploads/2018/10/Logo-300x87.pngGuillaume2009-11-21 15:43:332018-10-24 22:05:21Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study
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