Apparue dans les années 1980, la notion de biosimilaire désigne un produit biologique identique en tout point (forme et substance pharmaceutique, caractéristiques physicochimiques et biologiques) à un médicament biologique original (vaccin, anticorps, facteur de croissance, etc.) déjà commercialisé et dont le brevet est expiré.La démonstration de la similarité en termes de sécurité et d’efficacité entre les deux produits biologiques est un processus complexe qui requiert notamment de nouveaux essais précliniques

Contribution of IL22 to experimental skin inflammation

Focused on in vitro human models, we present the mechanisms of action of IL22 as well as its involvement in structure, metabolism, differentiation, chemotaxis, antibacterial activity, innate immunity, and tissue remodeling of epidermis.

Involvement of IL-1 and Oncostatin M in acanthosis associated with hypertensive leg ulcer

Hypertensive leg ulcer (HLU) is an inflammatory disease characterized by intense pain, alteration of vascularization, and skin necrosis. The optimal treatment relies on surgical removal of necrotic tissues covered by a split-skin graft.
CCL20 and beta-defensin-2

CCL20 and β-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions

These results indicate that Ag-specific activation will initially contribute to CCR6-mediated Th17 cell trafficking toward and sequestration in inflamed tissue, but that it eventually results in a transitory state of nonresponsiveness to further stimulation of these cells with CCR6 ligands, thus permitting their subsequent migration out of the inflamed site.
Human embryonic stem cell derivatives

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells' capability of constructing a pluristratified epidermis.

Moclobemide attenuates anoxia and glutamate induced neuronal damage in vitro independently of interaction with glutamate receptors subtypes

The present study examined the in vitro effects of the antidepressant and type-A monoamine oxidase inhibitor, moclobemide, in neuronal-astroglial cultures from rat cerebral cortex exposed to anoxia (for 5 and 7 h) or to glutamate (2 mM for 6 h), two in vitro models of brain ischemia.

in vitro effects of polyphenols from cocoa and beta-sitosterol on the growth of human prostate cancer and normal cells

The aim of this in vitro study was to evaluate the inhibitory effect of different cocoa polyphenols extracts, alone or combined with beta-sitosterol, on two human prostate cancer cell lines (nonmetastatic 22Rv1 cells and metastatic DU145 cells) and a normal human prostate cell line (RWEP-1)

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL-10, IL-22 has proinflammatory activities. IL-22 signals through a class II cytokine receptor composed of an IL-22-binding chain, IL-22RA1, and the IL-10RB subunit, which is shared with the IL-10R.