Labeling of normal human dermal fibroblasts (Myosin in green, actin in blue, nuclei in red)

Normal Human Dermal Fibroblasts (NHDF) in In Vitro Research

What are the applications of Normal Human Dermal Fibroblasts and how are they used in various studies? Learn about NHDF and its applications in this overview.

Immunolabeling

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QIMA Life Sciences offers immunolabeling (immunofluorescence & immunohistochemistry) and research & valdiation of antibody services.
Labeling of normal human epidermal keratinocytes

The NHEK in vitro Keratinocyte Model

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NHEK (Normal Human Epidermal Keratinocytes) have many applications in research. They can be used to study the function and disorders of the epidermis, so their use is very common in different fields.

Using Reconstructed Human Epidermis model in Skin Microbiome Research

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Skin microbiome research is developing rapidly. Are you up to date? Find out why 3D skin models are an important development in skin microbiome research.
Skin surface with hair_SEMX6000

Canities and hair pigmentation

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Canities (hair greying) has a wide-ranging social and cosmetic impact. QIMA Life Sciences is focusing on its physiopathology, underlying causes and treatments.
in vitro and ex vivo assays: skin barrier and hydration
Quantification of the IL-1 family member proteins in keratinocyte culture medium (A) and in keratinocyte extract (B)

Fibroblasts are potentially the key sensors of epidermis lesion through keratinocyte IL-1 signalling

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Our aim was to revisit the primary sterile epidermis lesion considering the alarmins constitutively expressed in the skin tissue and notably the IL-1 family members (IL-1fm) released by lesional keratinocytes. At homeostasis, the non-lesional epidermis constitutes a barrier against various external aggressions...

Profiling TLR agonist activity in keratinocytes and link to bacteria-induced innate immunity activation

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In this study, our goal was first to functionally profile and characterize the response of normal human keratinocytes (NHEK) to microbial patterns (TLR agonists) and IL-1α in parallel. To do so, the effects of multiple TLR agonists and IL-1α were evaluated on the gene expression profile, on signal transduction (NF-ƘB translocation) and also on IL-8 and IL-6 release. Secondly, we also tried to link these responses to those of pathogens of interest in skin microbiota (namely, C. acnes, S. aureus and P. aeruginosa), by evaluating the effect on IL-8 release by NHEK infected with living bacteria from these 3 strains...
GPDB: Chemical Compound Structure Database
CRO can become true collaborators in your research and be a source of new ideas and innovative solutions.

Key Questions to Ask When Choosing a CRO

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Partnering with a Preclinical CRO to assist your project can be an excellent idea. We will share five key questions you should ask before making up your mind regarding the CRO of your preference.
Photometry
Photometry

How are In Vitro Testing Methods Used for Cosmetics?

With the growing distaste and outright bans of animal testing of cosmetic products, more and more cosmetics companies are turning to in vitro testing. Let’s take a closer look at the nature of in vitro testing and the opportunities it offers for cosmetics brands and manufacturers.