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Cytokine-induced DEFB4 gene expressionCytokine-induced KRT10 gene expressionCytokine-induced S100A7 gene expression

RHE, gene expression (cytokine stimulation)

EPIBA-0006

  • Description
  • Requirement
  • Study and reporting
  • See also (6)
Biological Model

Reconstructed Epidermis, Bioalternatives RHE

Species

Human

EndPoint

mQPA-NHEK-PSO-16 | mQPA-NHEK-PSO-32 | mQPA-NHEK-PSO-64 | mRNA: e.g. DEFB4, S100A7, CXCL8, KRT10,...

Method

qPCRarray (standard or customized) | RT-qPCR | Transcriptome analysis

Stimulation Factor

OSM / IL-17 / TNF- alpha

Compound Reference

Jak inhibitor 1

Feasibility, study proposal:

Our sales team is here to help you find solutions:

  • Technical feasibility study of your project
  • Development of an assay selection strategy
  • Definition of an experimental scheme
  • Financial assessment and contractual agreements (costs, turnaround time, non-disclosure agreements, etc.)

Please do not hesitate to get in touch with us.

Price: our pricing system consists of a fixed price per study + pricing per unit (price per replicate or experimental condition)

Start of assays and turnaround time: the start of an assay is subject to the receipt of your agreement and of the compounds to be tested. The sending date of the study report is communicated by email when the study starts. Although of an average of 5 to 10 weeks, our turnaround time may be subject to some fluctuation (due to availability of biological samples, to workload, etc.).

Required quantity of compounds: the required quantity is generally of a few mg or ml but may vary according to the form and solubility of compounds and to the concentrations to be tested. Please contact us for an estimation.

Customized protocols: for this assay, as for all of our assays, we can develop a protocol adapted to your needs. Should you have any question, please contact us.

Study management: each project requires advice and expertise so each study is managed and monitored by a dedicated study director who will be attentive to all your needs and questions.

Validation: the assays listed in the catalogue have undergone a preliminary validation and are subject to Standard Operating Procedures (SOPs) and to validation criteria. However, the robustness of each assay may be different according to the models and to the analytical methods. Please do not hesitate to contact us for more information.

Report and experimental data: our services include the writing of a study report in English or in French. This scientific report is provided in a PDF or Microsoft® Office format.

Laboratory / Location: this assay (as all of our assays) will be carried out in our Gençay laboratory in France.

  • Placeholder

    NHDF, STAT1 activation (IFN- gamma stimulation)

    Add to cart Show Details
  • RHE, histology (cytokine stimulation)

    Add to cart Show Details
  • NHEK, antimicrobial peptide release (cytokine stimulation)

    Add to cart Show Details
  • NHEK, chemokine release (cytokine stimulation)

    Add to cart Show Details
  • NHEK, S100A7 expression (cytokine stimulation)

    Add to cart Show Details
  • NHEK, cytokeratin 10 expression (cytokine stimulation)

    Add to cart Show Details

Cosmetics

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Health animal and veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)

Online account and catalog access

Request your details

Posts and publications

  • New Biological Activities of Lythrum salicaria L.
  • Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract
  • Acne vulgaris: Origins, symptoms and current treatments
  • Acne vulgaris: physiopathology and cell mechanisms
  • Physiology and functions of the sebaceous gland

Headquarters

Bioalternatives SAS
1 bis rue des plantes BP 50011
86160 Gençay, France
Tel. +33 (0)5 49 36 11 37
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Hippocampal neuron network (glutamate-intoxicated)
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