https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/Acné-généralité-image-à-la-une-_-EN.jpg 368 655 Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Julie2017-11-29 09:31:592018-06-01 14:11:41Acne vulgaris: Origins, symptoms and current treatments
Acne vulgaris is a chronic inflammatory disease of the skin which affects most adolescents and is the cause of over half of all dermatology consultations. This pathology, which is characterized by a hypersecretion of sebum, can be the cause of physical complications and may also lead to psychological distress.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/Image-à-la-une.jpg 368 655 Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Julie2017-11-29 09:30:252018-06-01 14:10:54Acne vulgaris: physiopathology and cell mechanisms
Acne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes). Bioalternatives has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/Sébocytes-image-à-la-une.jpg 368 701 Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Julie2017-11-28 09:24:342018-06-01 14:11:31Physiology and functions of the sebaceous gland
The sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2015-04-09 15:47:492016-12-29 14:04:54Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662  constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1...) known to be androgen-sensitive in other androgenic cells and tissues.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2012-01-24 10:17:152016-12-29 14:05:00Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Keratinocytes-as-targets-for-cytokines.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2008-11-20 14:50:532016-12-05 12:05:34Keratinocytes as targets for cytokines in skin inflammation
Current knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Expression-of-type-5alpha-reductase.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2000-12-10 13:36:372016-12-05 12:12:53Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis
We analysed the potential of a human epidermal tissue reconstituted by cell culture (RHE, provided by SkinEthic Laboratories, Nice, France) as a model for assessing 5-alphaR activity.