Atopic dermatitis

AD is the most common dermatosis affecting children: 65% of the patients are less than a year old and 85% are below 5 years. The prevalence of this pathology is constantly on the rise and currently affects 10 to 25% of the population.

Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis

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Specific cytokine environment deregulation plays a central role on skin morphology and innate immunity, moving towards specific pathologies and opening the way to new therapeutic strategies.
cytokine

Atopic dermatitis – initiation and chemokines activation step

The skin lesions facilitate the passage of an antigen that the subject has previously been sensitized to.
atopic dermatitis

Atopic dermatitis – immune response and skin lesions

TH2/TH22 immune response and other agents of atopic dermatitis After polarization, the Th2 and Th22 TL migrate to the lesion area, where they release type Th2 (IL-4, IL-5, IL-13, IL-31, TNF-α) and Th22 (IL-22) cytokines respectively. These Th2/Th22 cytokines have different functions in the immunity response.
skin inflammation

Keratinocytes as targets for cytokines in skin inflammation

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Current knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis