https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_Depositphotos_pied-bébé.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2013-04-10 12:48:122017-05-15 13:19:40Atopic dermatitis: physio-pathology and clinical signs
Atopic dermatitis is the most common dermatosis affecting children: 65% of the patients are less than a year old and 85% are below 5 years. The prevalence of this pathology is constantly on the rise and currently affects 10 to 25% of the population.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_keratinocytes-under-fire.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2012-10-05 16:11:462016-12-05 12:00:40Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis
Specific cytokine environment deregulation plays a central role on skin morphology and innate immunity, moving towards specific pathologies and opening the way to new therapeutic strategies.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_Inflammatory-loop-ter-1.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2012-03-26 12:56:432017-05-15 11:35:46Atopic dermatitis - initiation and chemokines activation step
The skin lesions facilitate the passage of an antigen that the subject has previously been sensitized to.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_Eczema-sub-aigux20.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2012-03-25 13:01:112017-05-15 13:23:48Atopic dermatitis - immune response and skin lesions
TH2/TH22 immune response and other agents of atopic dermatitis After polarization, the Th2 and Th22 TL migrate to the lesion area, where they release type Th2 (IL-4, IL-5, IL-13, IL-31, TNF-α) and Th22 (IL-22) cytokines respectively. These Th2/Th22 cytokines have different functions in the immunity response.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Keratinocytes-as-targets-for-cytokines.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2008-11-20 14:50:532016-12-05 12:05:34Keratinocytes as targets for cytokines in skin inflammation
Current knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis