https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/09/mw_antibody-biosimalaireAdobeStock_3398206.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2016-09-19 11:09:302017-05-24 10:22:53Biosimilars
The term “biosimilar” emerged in the 1980s and describes a biological product identical in all respects (dosage form, active ingredient, chemical and biological characteristics) to an original, already marketed, biological drug (vaccine, antibody, growth factor, etc.) that is no longer under patent protection.La démonstration de la similarité en termes de sécurité et d’efficacité entre les deux produits biologiques est un processus complexe qui requiert notamment de nouveaux essais précliniques
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/06/mw_Fatty-acid-synthesis.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2016-06-03 13:48:322016-12-05 10:47:03Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast
Cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_IL22-IL22R-pathway-induces-cell-survival-in-human-gluolastoma-cells.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2015-03-20 16:06:292016-12-05 11:57:10IL22/IL-22R pathway induces cell survival in human glioblastoma cells
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_inhibition-of-keratinocyte-differentiation.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2014-07-10 16:22:302016-12-05 11:58:41Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M
This study highlights the precise role of cytokines in the skin inflammatory response (psoriasis). IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1α, IL-17A and TNFα were more involved in the activation of innate immunity.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/04/mw_expression-patterns-of-candidate-susceptibility.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2013-09-12 16:28:002016-12-05 12:15:00Expression patterns of candidate susceptibility genes HNF1β and CtBP2 in prostate cancer: Association with tumor progression
Genome-wide association studies have identified variants at multiple loci associated with prostate cancer (PCa) risk. Some of these loci include candidate susceptibility genes, such as MSMB, HNF1β, and C-terminal-binding protein (CtBP2). Except for MSMB, the clinicopathological significance of these genes has not been investigated. We therefore aimed to analyze their expression in PCa tissues, in relation with tumor progression and aggressiveness.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2013/04/mw_Contribution-of-IL-22.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2013-04-11 15:14:312016-12-05 11:59:28Contribution of IL22 to experimental skin inflammation
Focused on in vitro human models, we present the mechanisms of action of IL22 as well as its involvement in structure, metabolism, differentiation, chemotaxis, antibacterial activity, innate immunity, and tissue remodeling of epidermis.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_IL-1-and-Oncostatin-M.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2013-03-17 15:22:592016-12-05 11:59:51Involvement of IL-1 and Oncostatin M in acanthosis associated with hypertensive leg ulcer
Hypertensive leg ulcer (HLU) is an inflammatory disease characterized by intense pain, alteration of vascularization, and skin necrosis. The optimal treatment relies on surgical removal of necrotic tissues covered by a split-skin graft.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_The-gap-junction-protein-Cx43.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2012-02-11 10:42:322016-12-05 12:01:25The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells
We investigated the effect of the increased Cx43 expression, by retroviral infection, on the metastatic behaviour of two well-characterized cell lines (PC-3 and LNCaP) representing different stages of PCa progression. It appeared that Cx43 differently behaved in those cell lines and induced different phenotypes.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_CCL20-and-beta-defensin-2.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2011-02-01 11:13:042016-12-05 12:02:31CCL20 and β-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions
These results indicate that Ag-specific activation will initially contribute to CCR6-mediated Th17 cell trafficking toward and sequestration in inflamed tissue, but that it eventually results in a transitory state of nonresponsiveness to further stimulation of these cells with CCR6 ligands, thus permitting their subsequent migration out of the inflamed site.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Human-embryonic-stem-cell-derivatives.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2009-11-21 15:43:332016-12-29 14:05:16Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study
To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells' capability of constructing a pluristratified epidermis.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Moclobemide.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2007-03-23 09:20:042016-12-05 12:08:36Moclobemide attenuates anoxia and glutamate induced neuronal damage in vitro independently of interaction with glutamate receptors subtypes
The present study examined the in vitro effects of the antidepressant and type-A monoamine oxidase inhibitor, moclobemide, in neuronal-astroglial cultures from rat cerebral cortex exposed to anoxia (for 5 and 7 h) or to glutamate (2 mM for 6 h), two in vitro models of brain ischemia.
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Polyphenols.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2006-08-15 09:34:552016-12-05 12:09:19in vitro effects of polyphenols from cocoa and beta-sitosterol on the growth of human prostate cancer and normal cells
The aim of this in vitro study was to evaluate the inhibitory effect of different cocoa polyphenols extracts, alone or combined with beta-sitosterol, on two human prostate cancer cell lines (nonmetastatic 22Rv1 cells and metastatic DU145 cells) and a normal human prostate cell line (RWEP-1)
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_IL-22-inhibits-epidermal-differentiation.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2005-03-15 11:15:072016-12-05 12:11:29IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL-10, IL-22 has proinflammatory activities. IL-22 signals through a class II cytokine receptor composed of an IL-22-binding chain, IL-22RA1, and the IL-10RB subunit, which is shared with the IL-10R.