Bioalternatives has many in vitro or ex vivo models at your disposal:
- human epidermal keratinocyte stem cells (KSC)
- normal human epidermal keratinocytes (NHEK)
- reconstructed human epidermis (RHE)
- full thickness skin (FTSK)
- skin explants (ex vivo)
on which we can evaluate the effect of active compounds or formulations on epidermal regeneration and cell metabolism by measuring:
- cell viability and metabolism
- morphology, integrity and thickness of the epidermal tissue
- cell proliferation and migration
- clonogenicity (capacity of progenitor cells to form colonies)
- epidermal differentiation or dedifferentiation (differentiation markers: filaggrin, loricine, etc.), retinoid-like effects
Here are a few examples among all standard assays proposed by Bioalternatives in the field of epidermal regeneration:
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