EPIDERMAL REGENERATION

The epidermis is morphologically composed of distinct and stratified layers which reflect the sequential differentiation of keratinocytes that migrate from the basal layer to the superficial layer. Epidermal regeneration relies on the adequate balance between proliferation and differentiation of epidermal stem cells as well as on the removal of superficial dead cells (corneocytes) by desquamation, in order to maintain or to restore epidermal structure and functions.

Heredity, environment, lifestyle but also acne, inflammation, wound healing or ageing are factors that are known to have an impact on epidermal regeneration quality and speed.

The in vitro evaluation of an active or cosmetic compound on epidermal regeneration can be measured by analyzing the:

• cell migration and proliferation
• cell differentiation (retinoid-like effect)