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Bioalternatives
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HAIR GROWTH, ALOPECIA & CANITIES

Download a sample report

A person’s hair is often considered as a remnant of the animal mane and has both a social and biological role. It is characteristic of each person and is a sign of youth, health and fertility.

Hair loss (alopecia), unwanted hair growth (hirsutism, hypertrichosis) or premature graying of hair may lead to social, and possibly psychological, disorders for which the cosmetics industry is striving to find solutions.

Bioalternatives provides a model directly derived from the widely recognized standard conditions described by Philpott.  It is based on the immediate microdissection of human scalp samples, which makes the experimental procedure very exacting and dependent upon biological samples. This human hair follicle model is an isolated organ by itself and represents a “natural” model of co-culture of normal differentiated cutaneous cells (keratinocytes, but also fibroblasts and melanocytes).The hair-sebaceous unit is a complex system with cyclic self-renewal from a reserve of pluripotent cells. The hair renewal cycle varies according to many genetic, autocrine and paracrine factors as well as environmental ones.

These parameters can be analyzed using microscopy and morphometry methods but also via more complex molecular approaches (RT-qPCR, histology and immunohistochemistry, ELISA, etc.).

Hair growth, alopecia and canities: in vitro models and assays

Bioalternatives has the following in vitro or ex vivo models at your disposal:

  • human follicle dermal papilla fibroblasts (HFDPC)
  • human hair follicle (ex vivo)

on which we can evaluate the effects of active compounds on alopecia and hair growth by measuring:

  • hair growth stimulation (hair regeneration)
  • hair growth inhibition (anti-hair growth)
  • the increase in cell viability in culture (anti-apoptosis, anti-hair loss)
  • the increase of the hair shaft diameter
  • 5-alpha reductase activity (androgen metabolism)
  • hair bulb / hair shaft pigmentation
  • specific marker expression (Ki67, TGK, fibronectin, β-catenin, cytokines etc.)

Here are a few examples among all standard assays proposed by Bioalternatives in the field of hair growth and alopecia:

  • IL-8 release

    DPF, cytokine release ( IL-1 alpha stimulation)

    1.00€
    Add to cart Show Details
  • DPF proliferation

    DPF, proliferation (basal)

    1.00€
    Add to cart Show Details
  • DHT Testosterone ratio

    DPF, testosterone metabolism & 5- alpha reductase activity (basal)

    1.00€
    Add to cart Show Details
  • Normal

    Hair follicle growth & degeneration (basal)

    1.00€
    Add to cart Show Details
  • CCL2 gene expression

    Hair follicle, gene expression (cytokine mix)

    1.00€
    Add to cart Show Details
Find out about all our standard assays - Direct access to catalog A project, an idea or a question? Contact us and let’s talk about it!

SEE ALSO

Canities and hair pigmentation

4 December 2019/in Cosmetics, Hair follicle /by Vanessa

Canities (hair greying) has a wide-ranging social and cosmetic impact. Bioalternatives is focusing on its physiopathology, underlying causes and treatments.

Read more
https://www.bioalternatives.com/wp-content/uploads/2019/12/Note-application_canities_Figure2_1.jpg 658 979 Vanessa https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Vanessa2019-12-04 15:16:492019-12-04 15:18:29Canities and hair pigmentation

Hair: Follicle, Associated Structures and Growth

7 June 2017/in Cosmetics, Hair follicle /by Julie

Hair follicles are skin adnexa which are able to regenerate in a complete, autonomous, cyclic and asynchronous manner. The histological analysis of the pilosebaceous unit reveals a three-element organization: the epithelial compartment, the mesenchymal compartment and the sebaceous gland.

Read more
https://www.bioalternatives.com/wp-content/uploads/2017/06/Hair-follicle-web.jpg 803 540 Julie https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Julie2017-06-07 10:27:462019-09-13 21:57:10Hair: Follicle, Associated Structures and Growth

 

 

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Address

Bioalternatives, Inc.
250 Park Avenue, 7th Floor,
New York, NY, 10177, USA
Tel. +1 (212) 364 5115
Mail: info.us[@]bioalternatives.com

Bioalternatives SASU
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: info[@]bioalternatives.com

Latest posts

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  • Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
  • Evaluation of the anti-inflammatory and immunomodulatory effects of a product using in vitro canine whole blood models

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
© Copyright 2019 - Bioalternatives - Legal disclaimer
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