Bioalternatives has the following in vitro or ex vivo models at your disposal:
- human follicle dermal papilla fibroblasts (HFDPC)
- human hair follicle (ex vivo)
on which we can evaluate the effects of active compounds on alopecia and hair growth by measuring:
- hair growth stimulation (hair regeneration)
- hair growth inhibition (anti-hair growth)
- the increase in cell viability in culture (anti-apoptosis, anti-hair loss)
- the increase of the hair shaft diameter
- 5-alpha reductase activity (androgen metabolism)
- hair bulb / hair shaft pigmentation
- specific marker expression (Ki67, TGK, fibronectin, β-catenin, cytokines etc.)
Here are a few examples among all standard assays proposed by Bioalternatives in the field of hair growth and alopecia:
Hair: Follicle, Associated Structures and Growth
/in Cosmetics, Hair follicle /by JulieHair follicles are skin adnexa which are able to regenerate in a complete, autonomous, cyclic and asynchronous manner. The histological analysis of the pilosebaceous unit reveals a three-element organization: the epithelial compartment, the mesenchymal compartment and the sebaceous gland.