• Flickr
  • Gplus
  • Linkedin
  • Youtube
  • Français Français French fr
  • English English English en
LOG IN | CONTACT | +33 (0) 5 49 36 11 37
  • 0Shopping Cart
Bioalternatives
  • Bioalternatives
    • About us
    • Our team
    • Careers
    • Publications
  • Cosmetics
    • in vitro efficacy assays
      • Hydration and skin barrier
      • Epidermal regeneration
      • Skin firmness & cohesion
      • Skin ageing
      • Skin protection & defense
      • Skin pigmentation
      • Oily skin and hyperseborrhea
      • Skin microbiome
      • Slimming and adipocyte metabolism
      • Skin microcirculation and vascularization
      • Hair growth and alopecia
    • Bioanalysis and bioengineering
      • Cell and tissue engineering
      • Gene expression and transcriptomic analysis
      • Histology, Immunohistochemistry, Immunofluorescence
      • Development and validation of assays and protocols
  • Dermatology
    • Preclinical research
      • Acne
      • Skin microbiome
      • Alopecia and hair growth
      • Atopic dermatitis
      • Wound healing and skin regeneration
      • Psoriasis
      • Melanoma
      • Vitiligo (coming soon)
    • Bioanalysis and bioengineering
      • Cell and tissue engineering
      • Development and validation of assays and protocols
      • Gene expression and transcriptomic analysis
      • Histology, Immunohistochemistry, Immunofluorescence
  • Pharmacology
    • Therapeutic areas
      • Immuno-Inflammation
      • Health animal and veterinary medicine
      • Neurobiology
    • Bioanalysis and bioengineering
      • Cell and tissue engineering
      • Development and validation of assays and protocols
      • Gene expression and transcriptomic analysis
      • Histology, Immunohistochemistry, Immunofluorescence
  • Catalog
  • Menu

OILY SKIN AND HYPERSEBORRHEA

Oily skin is characterized by the accumulation on its surface of excess sebum, a substance secreted by sebaceous glands. Sebum is secreted by sebocytes through a process of cell differentiation and lipid synthesis or accumulation, called lipidogenesis.

Lipidogenesis is dependent on many factors (hormones, food, pharmaceutical active ingredients, xenobiotics, etc.), which can be identified in in vitro experiments. Mature sebocytes undergo apoptosis and burst to release sebum, which travels through the hair follicle to the skin surface. Sebum lubricates the hair follicle and spreads over the surface of the skin at the stratum corneum level.

An overproduction of sebum, called hyperseborrhea, is responsible for oily skin and greasy hair. In some cases, hyperseborrhea can also contribute to the development of acne prone skin.

Oily skin and hyperseborrhea: in vitro models and assays

Bioalternatives has many in vitro or ex vivo models at your disposal:

  • sebocyte cell line (SEBO662)
  • 3D sebocyte cell line (SEBO662 3D)
  • sebocyte cell line in response to androgens (SEBO662AR)

on which we can evaluate the effects of active ingredients or cosmetic formulations on sebaceous gland regulation and acne by measuring:

  • sebocyte differentiation and maturation  (EMA, KRT7, etc.)
  • lipidogenesis (lipid accumulation and production)
  • 5-alpha reductase activity and testosterone metabolism
3D sebocytes (SEBO662) (Oil Red O staining)
Labeling of sebocytes (SEBO662) (Bodipy in green, nuclei in blue)
Labeling of sebocytes (SEBO662) (Bodipy in green, cytokeratin 7 in red, nuclei in blue)
Labeling of SEBO662AR cells treated by DHT (Bodipy in green, EMA in red and nuclei in blue)
Load more

Here are a few examples among all assays proposed by Bioalternatives in the field of oily skin and hyperseborrhea:

  • SEBO662AR, sebocyte differentiation (testosterone stimulation)

    1.00€
    Add to cart Show Details
  • SEBO662AR, lipogenesis (testosterone stimulation)

    1.00€
    Add to cart Show Details
  • SEBO662AR, lipogenesis (lipogenic and androgenic factor stimulation)

    1.00€
    Add to cart Show Details
  • SEBO662AR, apolar lipid neosynthesis (testosterone stimulation)

    1.00€
    Add to cart Show Details
  • SEBO662AR, testosterone metabolism & 5- alpha reductase activity (basal)

    1.00€
    Add to cart Show Details

Discover all our standard assays related to oily skin and hyperseborrhoea

Direct access to catalog

Oily skin and hyperseborrhea: posts and publications

lipid

Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

29 November 2017/in Cosmetics, Sebaceous gland regulation, Skin protection and immune defense system /by Linhda Coulevard

Sebocytes lipid production are stimulated by pollutants. Ame acts by protecting epidermal cells, human sebocytes and skin from urban dust.

Read more
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/SEPPIC-Image-à-la-une.jpg 640 1140 Linhda Coulevard https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Linhda Coulevard2017-11-29 10:57:192017-11-29 11:44:39Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

Acne vulgaris: physiopathology and cell mechanisms

29 November 2017/in Acne, Sebaceous gland regulation /by Julie

Acne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes).
Bioalternatives has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.

Read more
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/Image-à-la-une.jpg 368 655 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2017-11-29 09:30:252018-02-26 10:19:51Acne vulgaris: physiopathology and cell mechanisms

Physiology and functions of the sebaceous gland

28 November 2017/in Acne, Sebaceous gland regulation, Skin barrier and hydration /by Julie

The sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.

Read more
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2017/11/Sébocytes-image-à-la-une.jpg 368 701 BA_Julie https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png BA_Julie2017-11-28 09:24:342018-02-13 10:44:49Physiology and functions of the sebaceous gland

Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

9 April 2015/in Acne, Cell and tissue engineering, Sebaceous gland regulation /by Guillaume

In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662 [17] constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1…) known to be androgen-sensitive in other androgenic cells and tissues.

Read more
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2015-04-09 15:47:492016-12-29 14:04:54Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

24 January 2012/in Acne, Cell and tissue engineering, Sebaceous gland regulation /by Guillaume

SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.

Read more
https://cdn-bneoicczbswi.netdna-ssl.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2017/03/logo-Bioalternatives-1.png Guillaume2012-01-24 10:17:152016-12-29 14:05:00Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

Cosmetics

  • Epidermal regeneration
  • Hair growth and alopecia
  • Hydration and skin barrier
  • Oily skin and hyperseborrhea
  • Skin ageing
  • Skin firmness & cohesion
  • Skin microbiome
  • Skin microcirculation and vascularization
  • Skin pigmentation
  • Skin protection & defense
  • Slimming and adipocyte metabolism

Cosmetics

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Health animal and veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)

Online account and catalog access

Request your details

Posts and publications

  • New Biological Activities of Lythrum salicaria L.
  • Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract
  • Acne vulgaris: Origins, symptoms and current treatments
  • Acne vulgaris: physiopathology and cell mechanisms
  • Physiology and functions of the sebaceous gland

Headquarters

Bioalternatives SAS
1 bis rue des plantes BP 50011
86160 Gençay, France
Tel. +33 (0)5 49 36 11 37
Legal notice
© Copyright 2016 - Bioalternatives
  • Flickr
  • Gplus
  • Linkedin
  • Youtube
Login

Lost your password?

Create my account

Reset Password

Log in

This site uses cookies only to collect information about how visitors use our site. By continuing to navigate this site, you accept our use of cookies.Ok
Scroll to top