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Bioalternatives
  • Bioalternatives
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  • Cosmetics
    • Hydration and skin barrier
    • Epidermal regeneration
    • Skin firmness & cohesion
    • Skin ageing
    • Skin protection & defense
    • Skin pigmentation
    • Oily skin and hyperseborrhea
    • Skin microbiota
    • Slimming and adipocyte metabolism
    • Skin microcirculation and vascularization
    • Hair growth, alopecia & canities
  • Dermatology
    • Acne
    • Skin microbiota
    • Alopecia, hair growth & canities
    • Atopic dermatitis
    • Wound healing and skin regeneration
    • Psoriasis
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    • Vitiligo (coming soon)
  • Pharmacology
    • Immuno-Inflammation
    • Veterinary medicine
    • Neurobiology
  • Bioanalysis and bioengineering
    • Analytical and bioanalytical services
      • Bioanalysis of non-invasive clinical samples
    • Cell and tissue engineering
    • Chemoinformatics, in silico virtual screening & phytochemical profiling
      • in silico screening – SELNERGY
      • Phytochemical analysis & metabolic profiling – GAINS
    • Gene expression and transcriptomic analysis
      • RNA extraction and quality control
      • Rt-qPCR & PCRarrays
      • Microarrays
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      • In situ hybridization
      • Bioinformatics
    • Histology services
      • Slide preparation
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      • Slide scanning
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SKIN MICROCIRCULATION

& VASCULARIZATION

Skin microcirculation is located in the dermis and hypodermis layers. It plays a significant role in skin homeostasis (transportation of gases, nutrients, waste, hormones), in body thermoregulation, in blood pressure regulation and in inflammatory response.

Dermal arterioles and venules are composed of endothelial cells, connective tissues (collagen, elastin) and of smooth muscle cells which allow vessel vasoconstriction and vasodilation. Dermal capillaries are composed of a single layer of endothelial cells and of pericytes surrounded by a basal membrane.

A microcirculation dysfunction due to external factors (e.g. sun exposure, heat, cold, microorganisms and food) or internal factors (immune system) can cause redness, venous insufficiency or rosacea. Microcirculation is also altered by skin ageing, with a progressive decrease of new blood vessel formation (angiogenesis). This age-related alteration of skin microcirculation may have different consequences: sensation of cold, pallor, cutaneous ischemia, alopecia, etc.

Skin microcirculation and vascularization: in vitro models and assays

Bioalternatives has many in vitro models at your disposal:

  • Human umbilical vein endothelial cells (HUVEC)
  • Human dermal microvascular endothelial cells (HMVEC-d)
  • HMVEC-d and NHDF coculture (ENDOF)
  • Human aortic smooth muscle cells (AoSMC)
  • Other skin cells (NHEK, NHDF, etc.) 

on which we can evaluate the effect of active cosmetic compounds on skin microvascularization by measuring:

  • Viability, proliferation and migration of endothelial cells
  • Cell differentiation and pseudotube (angiogenesis, neovascularization) formation
  • Protection of endothelial cells against stress (inflammation, infection, etc.)  
  • Veinotonic activity of smooth muscle cells
  • Angiogenic factor release (e.g.VEGF)

Here are a few examples among all assays proposed by Bioalternatives in the field of microvascularization:

  • Calcium mobolization

    AoSMC, veinotonic activity (basal)

    1.00€
    Add to cart Show Details
  • ICAM-1 expression#Ref

    HUVEC, ICAM-1 expression (TNF- alpha stimulation)

    1.00€
    Add to cart Show Details
  • VEGF release

    NHDF, VEGF release (basal)

    1.00€
    Add to cart Show Details
  • Pseudotube-formation#Ctrl

    HMVEC + NHDF, differentiation/pseudotube formation (basal, pro-angiogenic agents)

    1.00€
    Add to cart Show Details
  • Pseudotube formation

    HMVEC + NHDF, differentiation/pseudotube formation (VEGF stimulation, anti-angiogenic agents)

    1.00€
    Add to cart Show Details
Find out about all our standard assays - Direct access to catalog A project, an idea or a question? Contact us and let’s talk about it!

 

 

NEED MORE INFORMATION?

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Address

Bioalternatives, Inc.
250 Park Avenue, 7th Floor,
New York, NY, 10177, USA
Tel. +1 (212) 364 5115
Mail: info.us[@]bioalternatives.com

Bioalternatives SASU
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: info[@]bioalternatives.com

Latest posts

  • Effects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs
  • Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
  • Evaluation of the anti-inflammatory and immunomodulatory effects of a product using in vitro canine whole blood models

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
© Copyright 2019 - Bioalternatives - Legal disclaimer
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