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Bioalternatives
  • Bioalternatives
    • About us
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  • Cosmetics
    • in vitro efficacy assays
      • Hydration and skin barrier
      • Epidermal regeneration
      • Skin firmness & cohesion
      • Skin ageing
      • Skin protection & defense
      • Skin pigmentation
      • Oily skin and hyperseborrhea
      • Skin microbiome
      • Slimming and adipocyte metabolism
      • Skin microcirculation and vascularization
      • Hair growth and alopecia
    • Bioanalysis and bioengineering
      • Cell and tissue engineering
      • Gene expression and transcriptomic analysis
      • Histology, Immunohistochemistry, Immunofluorescence
      • Development and validation of assays and protocols
  • Dermatology
    • Preclinical research
      • Acne
      • Skin microbiome
      • Alopecia and hair growth
      • Atopic dermatitis
      • Wound healing and skin regeneration
      • Psoriasis
      • Melanoma
      • Vitiligo (coming soon)
    • Bioanalysis and bioengineering
      • Cell and tissue engineering
      • Development and validation of assays and protocols
      • Gene expression and transcriptomic analysis
      • Histology, Immunohistochemistry, Immunofluorescence
  • Pharmacology
    • Therapeutic areas
      • Immuno-Inflammation
      • Health animal and veterinary medicine
      • Neurobiology
    • Bioanalysis and bioengineering
      • Cell and tissue engineering
      • Development and validation of assays and protocols
      • Gene expression and transcriptomic analysis
      • Histology, Immunohistochemistry, Immunofluorescence
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SKIN MICROCIRCULATION

VASCULARIZATION

Skin microcirculation is located in the dermis and hypodermis layers. It plays a significant role in skin homeostasis (transportation of gases, nutrients, waste, hormones), in body thermoregulation, in blood pressure regulation and in inflammatory response.

Dermal arterioles and venules are composed of endothelial cells, connective tissues (collagen, elastin) and of smooth muscle cells which allow vessel vasoconstriction and vasodilation. Dermal capillaries are composed of a single layer of endothelial cells and of pericytes surrounded by a basal membrane.

A microcirculation dysfunction due to external factors (e.g. sun exposure, heat, cold, microorganisms and food) or internal factors (immune system) can cause redness, venous insufficiency or rosacea. Microcirculation is also altered by skin ageing, with a progressive decrease of new blood vessel formation (angiogenesis). This age-related alteration of skin microcirculation may have different consequences: sensation of cold, pallor, cutaneous ischemia, alopecia, etc.

Skin microcirculation and vascularization: in vitro models and assays

Bioalternatives has many in vitro models at your disposal:

  • Human umbilical vein endothelial cells (HUVEC)
  • Human dermal microvascular endothelial cells (HMVEC-d)
  • HMVEC-d and NHDF coculture (ENDOF)
  • Human aortic smooth muscle cells (AoSMC)
  • Other skin cells (NHEK, NHDF, etc.) 

on which we can evaluate the effect of active cosmetic compounds on skin microvascularization by measuring:

  • Viability, proliferation and migration of endothelial cells
  • Cell differentiation and pseudotube (angiogenesis, neovascularization) formation
  • Protection of endothelial cells against stress (inflammation, infection, etc.)  
  • Veinotonic activity of smooth muscle cells
  • Angiogenic factor release (e.g.VEGF)
HUVEC, ICAM-1 expression (TNF-alpha stimulation)
HMVEC, differentiation (basal)
AoSMC
HUVEC

Here are a few examples among all assays proposed by Bioalternatives in the field of microvascularization:

  • AoSMC, veinotonic activity (basal)

    1.00€
    Add to cart Show Details
  • HUVEC, ICAM-1 expression (TNF- alpha stimulation)

    1.00€
    Add to cart Show Details
  • NHDF, VEGF release (basal)

    1.00€
    Add to cart Show Details
  • HMVEC + NHDF, differentiation/pseudotube formation (basal, pro-angiogenic agents)

    1.00€
    Add to cart Show Details
  • HMVEC + NHDF, differentiation/pseudotube formation (VEGF stimulation, anti-angiogenic agents)

    1.00€
    Add to cart Show Details

Discover all our standard assays related to skin microcirculation and vascularization

Direct access to catalog

Cosmetics

  • Epidermal regeneration
  • Hair growth and alopecia
  • Hydration and skin barrier
  • Oily skin and hyperseborrhea
  • Skin ageing
  • Skin firmness & cohesion
  • Skin microbiome
  • Skin microcirculation and vascularization
  • Skin pigmentation
  • Skin protection & defense
  • Slimming and adipocyte metabolism

Cosmetics

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Health animal and veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)

Online account and catalog access

Request your details

Posts and publications

  • New Biological Activities of Lythrum salicaria L.
  • Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract
  • Acne vulgaris: Origins, symptoms and current treatments
  • Acne vulgaris: physiopathology and cell mechanisms
  • Physiology and functions of the sebaceous gland

Headquarters

Bioalternatives SAS
1 bis rue des plantes BP 50011
86160 Gençay, France
Tel. +33 (0)5 49 36 11 37
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