Bioalternatives has many in vitro models at your disposal:
- Human umbilical vein endothelial cells (HUVEC)
- Human dermal microvascular endothelial cells (HMVEC-d)
- HMVEC-d and NHDF coculture (ENDOF)
- Human aortic smooth muscle cells (AoSMC)
- Other skin cells (NHEK, NHDF, etc.)
on which we can evaluate the effect of active cosmetic compounds on skin microvascularization by measuring:
- Viability, proliferation and migration of endothelial cells
- Cell differentiation and pseudotube (angiogenesis, neovascularization) formation
- Protection of endothelial cells against stress (inflammation, infection, etc.)
- Veinotonic activity of smooth muscle cells
- Angiogenic factor release (e.g.VEGF)
Here are a few examples among all assays proposed by Bioalternatives in the field of microvascularization:
