Psoriasis is a non-contagious inflammatory skin disease linked to a genetic predisposition and which develops under the influence of environmental parameters. While no treatment can completely cure this autoimmune disease, psoriasis is the subject of intensive research and especially so since the identification of subpopulations of Th17 and Th22 lymphocytes.
Psoriasis: in vitro models and assays
With the assistance of its academic partners (Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC, EA 4331) and hospital partners (University Hospital Center of Poitiers), Bioalternatives has carried out an extensive research program on psoriasis for more than a decade. Our work is particularly aimed at better characterizing the role as well as the individual or combined effects of Th1, Th17 and Th22 cytokines (e.g. IL-17A, IL-22, IL-1alpha, OSM and TNF-alpha) on the development of cutaneous inflammation and inhibition of skin differentiation. Today Bioalternatives offers a full range of innovative models and in vitro pharmacology assays specifically dedicated to the evaluation of pharmacological efficacy (screening, profiling, proof-of-concept) of your products (APIs, biosimilars, formulations, medical devices):
- Immune response (Th17/Th22 cytokine release)
- Induction in keratinocytes (or reconstructed epidermis) of a psoriasis-like profile by cytokines
- Production of chemokines, antimicrobial peptides (AMPs) and expression of epidermal differentiation markers
- Specific marker analysis by immunoassays or RT-qPCR
Here are a few examples among all the standard assays proposed by Bioalternatives in the field of psoriasis:
Psoriasis: clinical bioanalysis
Analysis of markers of inflammation
Our company has developed ready-to-use non-invasive collection kits to analyze the lipids and biomarkers of the skin surface from your samples or from those of your clinical center.
The markers of inflammation are also analyzed from samples using the SW Kit (cytokines, cascade of fatty acids, PGE2).
These evaluations help support your claims about the efficacy of soothing skincare products, protective products, anti-inflammatory products, etc.
Screening of inflammation markers