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Bioalternatives
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PSORIASIS

Download a sample report

Psoriasis is a non-contagious inflammatory skin disease linked to a genetic predisposition and which develops under the influence of environmental parameters. While no treatment can completely cure this autoimmune disease, psoriasis is the subject of intensive research and especially so since the identification of subpopulations of Th17 and Th22 lymphocytes.

Psoriasis: in vitro models and assays

With the assistance of its academic partners (Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC, EA 4331) and hospital partners (University Hospital Center of Poitiers),   Bioalternatives has carried out an extensive research program on psoriasis for more than a decade. Our work is particularly aimed at better characterizing the role as well as the individual or combined effects of Th1, Th17 and Th22 cytokines (e.g.  IL-17A, IL-22, IL-1alpha, OSM and TNF-alpha) on the development of cutaneous inflammation and inhibition of skin differentiation. Today Bioalternatives offers a full range of innovative models and in vitro pharmacology assays specifically dedicated to the evaluation of pharmacological efficacy (screening, profiling, proof-of-concept) of your products (APIs, biosimilars, formulations, medical devices):

  • Immune response (Th17/Th22 cytokine release)
  • Induction in keratinocytes (or reconstructed epidermis) of a  psoriasis-like profile by cytokines
  • Production of chemokines, antimicrobial peptides (AMPs) and expression of epidermal differentiation markers
  • Specific marker analysis by immunoassays or RT-qPCR

Here are a few examples among all the standard assays proposed by Bioalternatives in the field of psoriasis:

  • DEFB4 gene expression

    NHEK, gene expression (cytokine stimulation)

    1.00€
    Add to cart Show Details
  • Cytokine-induced DEFB4 gene expression

    RHE, gene expression (cytokine stimulation)

    1.00€
    Add to cart Show Details
  • HE staining#Stim

    RHE, histology (cytokine stimulation)

    1.00€
    Add to cart Show Details
  • Beta defensin 2 release

    NHEK, antimicrobial peptide release (cytokine stimulation)

    1.00€
    Add to cart Show Details
  • IL-8 release

    NHEK, chemokine release (cytokine stimulation)

    1.00€
    Add to cart Show Details

Psoriasis: clinical bioanalysis

Analysis of markers of inflammation

Our company has developed ready-to-use non-invasive collection kits to analyze the lipids and biomarkers of the skin surface from your samples or from those of your clinical center.

The markers of inflammation are also analyzed from samples using the SW Kit (cytokines, cascade of fatty acids, PGE2).

These evaluations help support your claims about the efficacy of soothing skincare products, protective products, anti-inflammatory products, etc.

Screening des marqueurs de l'inflammation

Screening of inflammation markers

Find out about all our standard assays - Direct access to catalog
A project, an idea or a question? Contact us and let’s talk about it!

Psoriasis: posts and publications

Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis

Psoriasis

Acute-serum Amyloid A (A-SAA), one of the major acute-phase proteins, is mainly produced in the liver but extra-hepatic synthesis involving the skin has been reported. Its expression is regulated by the transcription factors NF-κB, C/EBPβ, STAT3 activated by proinflammatory cytokines.

Read more
14 July 2017/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2017/08/IL-17A.png 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2017-07-14 09:37:162019-08-01 15:20:02Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
imiquimod

Imiquimod-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome

Psoriasis

The pathogenesis of inflammatory skin diseases such as psoriasis involves the release of numerous proinflammatory cytokines, including members of the IL-1 family. Here we report overexpression of IL-1α, IL-1β, and IL-1 receptor antagonist mRNA, associated to expression of IL-23p19, IL-17A, and IL-22 in skin cells

Read more
24 July 2015/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/03/mw_imq-induced-skin-inflammation.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2015-07-24 17:30:202018-10-24 21:56:11Imiquimod-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome

Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M

Inflammation, Psoriasis

This study highlights the precise role of cytokines in the skin inflammatory response (psoriasis). IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1α, IL-17A and TNFα were more involved in the activation of innate immunity.

Read more
10 July 2014/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/03/mw_inhibition-of-keratinocyte-differentiation.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2014-07-10 16:22:302018-10-24 22:00:08Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M

Contribution of IL22 to experimental skin inflammation

Inflammation, Psoriasis

Focused on in vitro human models, we present the mechanisms of action of IL22 as well as its involvement in structure, metabolism, differentiation, chemotaxis, antibacterial activity, innate immunity, and tissue remodeling of epidermis.

Read more
11 April 2013/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2013/04/mw_Contribution-of-IL-22.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2013-04-11 15:14:312018-10-24 22:00:41Contribution of IL22 to experimental skin inflammation

Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis

Atopic dermatitis, Dermatite atopique, Psoriasis

Specific cytokine environment deregulation plays a central role on skin morphology and innate immunity, moving towards specific pathologies and opening the way to new therapeutic strategies.

Read more
5 October 2012/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_keratinocytes-under-fire.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2012-10-05 16:11:462019-11-12 17:47:46Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis

Skin inflammation induced by the synergistic action of IL17A, IL22, OSM, IL1α and TNFα recapitulates some features of psoriasis

Psoriasis

Our results demonstrate the important potentiating activities of IL17A, IL22, oncostatin M, TNF-alpha, and IL1alpha on keratinocytes. This is particularly interesting in the context of psoriasis where these cytokines are overexpressed and could synergize to play an important role in upregulation of chemokines and antimicrobial peptides production.

Read more
26 March 2010/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Skin-inflammation-induced-by-the-synergistic-action-of-IL-17A.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2010-03-26 15:25:302018-10-24 22:04:30Skin inflammation induced by the synergistic action of IL17A, IL22, OSM, IL1α and TNFα recapitulates some features of psoriasis
skin inflammation

Keratinocytes as targets for cytokines in skin inflammation

Acne, Atopic dermatitis, Dermatology, Psoriasis

Current knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis

Read more
20 November 2008/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Keratinocytes-as-targets-for-cytokines.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2008-11-20 14:50:532019-05-31 09:36:35Keratinocytes as targets for cytokines in skin inflammation
CEACAM1

Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils

Psoriasis

These results show that cytokine-induced cell-surface expression of CEACAM1 by keratinocytes in the context of a psoriatic environment might contribute to the persistence of neutrophils and thus to ongoing inflammation and the decreased propensity for skin infection, typical for patients with psoriasis.

Read more
9 October 2008/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Cytokine-induced-CEACAM1-expression.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2008-10-09 13:29:202018-10-24 22:06:33Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils
interleukin 22

A role for T cell-derived interleukin 22 in psoriatic skin inflammation

Psoriasis

This study indicate that interleukin 22 is a cytokine produced by skin-infiltrating lymphocytes that is potentially involved in initiation and/or maintenance of the pathogenesis of psoriasis.

Read more
27 September 2007/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2007/09/mw_T-cell-derived-interleukin-22.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2007-09-27 16:47:372018-10-24 22:11:29A role for T cell-derived interleukin 22 in psoriatic skin inflammation
OSM

OSM (Oncostatin M) secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation

Psoriasis

These results demonstrate that OSM and its receptor play an important role in cutaneous inflammatory responses in general and that the specific effects of OSM are associated with distinct inflammatory diseases depending on the cytokine environment.

Read more
1 April 2007/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Oncostatin-M.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2007-04-01 08:56:232018-10-24 22:11:40OSM (Oncostatin M) secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation
IL10

Keratinocytes as targets for IL10-related cytokines : a putative role in psoriasis pathogenesis

Psoriasis

In this review, we discuss recent knowledge about the effects of cytokines of the IL-10 family on keratinocytes and their potential role in psoriasis, a cutaneous inflammatory disease.

Read more
15 December 2005/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Keratinocytes-as-targets-for-IL-10-related-cytokines.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2005-12-15 09:47:352018-10-24 22:13:04Keratinocytes as targets for IL10-related cytokines : a putative role in psoriasis pathogenesis
IL-22

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

Inflammation, Psoriasis

IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL-10, IL-22 has proinflammatory activities. IL-22 signals through a class II cytokine receptor composed of an IL-22-binding chain, IL-22RA1, and the IL-10RB subunit, which is shared with the IL-10R.

Read more
15 March 2005/by Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_IL-22-inhibits-epidermal-differentiation.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2005-03-15 11:15:072018-10-24 22:14:26IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

 

 

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Address

Bioalternatives, Inc.
250 Park Avenue, 7th Floor,
New York, NY, 10177, USA
Tel. +1 (212) 364 5115
Mail: info.us[@]bioalternatives.com

Bioalternatives SASU
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: info[@]bioalternatives.com

Latest posts

  • Effects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs
  • Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
  • Evaluation of the anti-inflammatory and immunomodulatory effects of a product using in vitro canine whole blood models

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
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