Physiology and functions of the sebaceous gland
Sebum composition and function
Regulation of sebum production under normal conditions
Other regulatory factors
Besides the effects of androgen hormones, there are other factors which regulate lipid synthesis.
- Endogenous factors: the lipogenic activity may be influenced by other non-hormonal endogenous lipogenic factors, such as the products of fatty acid metabolism, such as cholesterol or cholecalciferol (vitamin D), or by some molecules of the retinoid family and of its derivatives such as retinoic acid, retinol or vitamin A [Assay: SEBOAR-0019].
- Environmental / exogenous factors: they are implicated in the quality and quantity of secreted sebum.
- Pollution: whether natural or due to human activity (ozone, industry, farming, smoking, etc.), it affects the composition of sebum and is also thought to stimulate its secretion
- Exposure to UV: skin damage caused by the sun’s UV radiation is also a factor with an impact on the quality of the sebum present on the skin surface
- Diet: the presence in diet of certain nutrients, such as certain types of fatty acids (e.g. cholesterol) is also thought to have an impact on the regulation and the quality of the secreted sebum [Assay: SEBOAR-0009]