• Flickr
  • LinkedIn
  • Youtube
SE CONNECTER | CONTACT | +33 (0) 5 49 36 11 37
  • Français
  • English
  • 中文
  • Português
  • 0Shopping Cart
Bioalternatives
  • Bem vindos à Bioalternatives
    • Quem somos
    • Nossa equipe
    • Publications
    • Carreiras
  • Cosméticos
    • Hidratação e barreira da pele
    • Regeneração epidérmica
    • Firmeza e coesão da pele
    • Envelhecimento da pele
    • Proteção e defesa da pele
    • Pigmentação da pele
    • Pele oleosa e hiperseborreia
    • Microbioma cutâneo
    • Emagrecimento e metabolismo de adipócito
    • Microcirculação e vascularização da pele
    • Crescimento capilar e alopecia
  • Dermatologia
    • Acne
    • Crescimento capilar e alopecia
    • Cicatrização de ferimentos e regeneração cutânea
    • Dermatite atópica
    • Psoríase
    • Microbioma cutâneo
    • Melanoma
  • Farmacologia in vitro
    • Imuno-inflamação
    • Neurobiologia
    • Saúde animal e medicina veterinária
  • Bioanálise e bioengenharia
    • Engenharia de células e tecidos
    • Quimioinformática, screening virtual in silico & caracterização fitoquímica
      • Screening in silico – SELNERGY
      • Análise fitoquímica & caracterização metabólica – GAINS
    • Expressão de genes e análise do transcriptoma
    • Histologia, imuno-histoquímica, imunofluorescência
      • Coloração histológica
      • Imunomarcação
      • Serviço de microscopia eletrônica – TEM / SEM
  • Menu Menu

ACNE

Faça o download de uma amostra de nossos relatórios

A acne é uma patologia inflamatória crônica dos folículos pilossebáceos em dependência hormonal que inclui:

  • aumento anormal de produção de lipídeo sebáceo (sebo)
  • formação de microcomedões devido à diferenciação epidérmica anormal, uma consequência provável do metabolismo anormal do andrógeno (testosterona)
  • acúmulo de lipídeos peroxidados na superfície (cravos) ou dentro do foliculo piloso dilatado (comedão)
  • formação de lesões inflamatórias infecciosas e não infecciosas e processo de cicatrização de ferimento cutâneo

Acne: modelos e ensaios in vitro

A Bioalternatives apresenta muitos modelos in vitro ou ex vivo relacionados à acne à sua disposição:

  • Sebócitos humanos: linhagens celulares SEBO662 e SEBO662AR
  • Queratinócitos epidérmicos humanos normais (NHEK)
  • Fibroblastos dérmicos humanos normais (NHDF)
  • Células papilares dérmicas de folículo humano (HFDPC)
  • Epiderme humana reconstruída (RHE)

A Bioalternatives fornece uma variedade de modelos e ensaios farmacológicos inovadores in vitro, mais especialmente voltados à avaliação da eficácia farmacológica (screening, caracterização, demostraçao de validade do conceito) dos seus produtos (APIs, biossimilares, formulações, dispositivos médicos):

  • Regulação da glândula sebácea e hiperseborréia
  • Metabolismo do andrógeno
  • Diferenciação epidérmica anormal
  • Peroxidação lipídica
  • Resposta inflamatória, à lesão ou microbiana
  • Infecção, sistema imunológico e defesas da pele

Aqui encontram-se alguns exemplos dentre todos os ensaios propostos pela Bioalternatives sobre acne:

  • Beta defensin 2 release

    NHEK, antimicrobial peptide release (basal)

    1.00€
    Comprar Show Details
  • Lipid content

    SEBO662AR, lipogenesis (lipogenic and androgenic stimulation)

    1.00€
    Comprar Show Details
  • Lipid content

    SEBO662AR, lipogenesis (testosterone stimulation)

    1.00€
    Comprar Show Details
  • DHT testosterone ratio

    Sebocytes, testosterone metabolism & 5- alpha reductase activity (basal)

    1.00€
    Comprar Show Details
Descubra todos os nossos ensaios padrão - Acesso direto ao catálogo Um projeto, uma idéia ou uma pergunta? Vamos conversar. Entre em contato!

Acne: posts e publicações

Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiome

Acne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.

Leia mais
22 maio 2019/por Vanessa
https://www.bioalternatives.com/wp-content/uploads/2019/05/190527_Poster1_petit.png 368 655 Vanessa https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Vanessa2019-05-22 14:37:542019-11-12 17:58:17Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Acne, Sebaceous gland regulation

We analysed the activity of reference anti-androgens (Finasteride, Dutasteride, Cyproterone acetate), at the level of their potential targets (5-alpha-reductase, AR translocation, induced transcripts) and in a functional lipid accumulation assay. We also evaluated this androgen-induced lipid accumulation assay as a potential pharmacological tool to detect potential inhibitors from both androgenic and non-androgenic origins.

Leia mais
22 maio 2019/por Vanessa
https://www.bioalternatives.com/wp-content/uploads/2019/05/190527_Poster3_petit.png 368 655 Vanessa https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Vanessa2019-05-22 14:37:122019-11-12 17:36:48Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.

Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation

Androgens are key regulators of sebaceous function… A link between mTOR and androgen signaling has previously been reported…as well as a link between these processes and lipid synthesis…Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.

Leia mais
22 maio 2019/por Vanessa
https://www.bioalternatives.com/wp-content/uploads/2019/05/190527_Poster4_petit.png 368 655 Vanessa https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Vanessa2019-05-22 14:37:042019-11-12 17:39:16Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Various forms of acne vulgaris

Acne vulgaris: Origins, symptoms and current treatments

Acne

Acne vulgaris is a chronic inflammatory disease of the skin which affects most adolescents and is the cause of over half of all dermatology consultations. This pathology, which is characterized by a hypersecretion of sebum, can be the cause of physical complications and may also lead to psychological distress.

Leia mais
29 novembro 2017/por Julie
https://www.bioalternatives.com/wp-content/uploads/2017/11/Acné-généralité-image-à-la-une-_-EN.jpg 368 655 Julie https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Julie2017-11-29 09:31:592019-11-12 14:28:03Acne vulgaris: Origins, symptoms and current treatments

Acne vulgaris: physiopathology and cell mechanisms

Acne, Sebaceous gland regulation

Acne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes).
Bioalternatives has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.

Leia mais
29 novembro 2017/por Julie
https://www.bioalternatives.com/wp-content/uploads/2017/11/Image-à-la-une.jpg 368 655 Julie https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Julie2017-11-29 09:30:252019-09-13 07:40:20Acne vulgaris: physiopathology and cell mechanisms

Physiology and functions of the sebaceous gland

Acne, Sebaceous gland regulation, Skin barrier and hydration

The sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.

Leia mais
28 novembro 2017/por Julie
https://www.bioalternatives.com/wp-content/uploads/2017/11/Sébocytes-image-à-la-une.jpg 368 701 Julie https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Julie2017-11-28 09:24:342019-11-07 15:45:07Physiology and functions of the sebaceous gland

Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Acne, Cell and tissue engineering, Sebaceous gland regulation

In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662 [17] constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1…) known to be androgen-sensitive in other androgenic cells and tissues.

Leia mais
9 abril 2015/por Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2015-04-09 15:47:492019-11-13 11:16:58Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

Acne, Cell and tissue engineering, Sebaceous gland regulation

SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.

Leia mais
24 janeiro 2012/por Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2012-01-24 10:17:152019-11-13 11:28:55Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
skin inflammation

Keratinocytes as targets for cytokines in skin inflammation

Acne, Atopic dermatitis, Dermatology, Psoriasis

Current knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis

Leia mais
20 novembro 2008/por Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Keratinocytes-as-targets-for-cytokines.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2008-11-20 14:50:532019-05-31 09:36:35Keratinocytes as targets for cytokines in skin inflammation
5-alpha-reductase

Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis

Acne, Dermatology

We analysed the potential of a human epidermal tissue reconstituted by cell culture (RHE, provided by SkinEthic Laboratories, Nice, France) as a model for assessing 5-alphaR activity.

Leia mais
10 dezembro 2000/por Guillaume
https://www.bioalternatives.com/wp-content/uploads/2016/05/mw_Expression-of-type-5alpha-reductase.jpg 368 655 Guillaume https://www.bioalternatives.com/wp-content/uploads/2019/09/Logo-Bioalternatives-150dpisite-web2-300x74.png Guillaume2000-12-10 13:36:372018-10-24 22:15:34Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis

 

 

PRECISA DE MAIS INFORMAÇÃO?

  • Este campo é para fins de validação e não deve ser alterado.

Address

Bioalternatives, Inc.
250 Park Avenue, 7th Floor,
New York, NY, 10177, USA
Tel. +1 (212) 364 5115
Mail: info.us[@]bioalternatives.com

Bioalternatives SASU
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: info[@]bioalternatives.com

Latest posts

  • Serviço de microscopia eletrônica – TEM / SEM
  • Coloração histológica
  • Imunomarcação

Páginas

  • Acne
  • Bem vindos à Bioalternatives
  • Carreiras
  • Cicatrização de ferimentos e regeneração cutânea
  • Cosméticos
  • Crescimento capilar e alopecia
  • Dermatite atópica
  • Dermatologia
  • Emagrecimento e metabolismo de adipócito
  • Engenharia de células e tecidos
  • Envelhecimento da pele
  • Expressão de genes e análise do transcriptoma
  • Farmacologia in vitro
  • Firmeza e coesão da pele
  • Formulaire – Entre em contato com nossa equipe
  • Hidratação e barreira da pele
  • Histologia, imuno-histoquímica, imunofluorescência
  • Imuno-inflamação
  • Melanoma
  • Microbioma cutâneo
  • Microcirculação e vascularização da pele
  • Neurobiologia
  • Nossa equipe
  • Pele oleosa e hiperseborreia
  • Pigmentação da pele
  • Proteção e defesa da pele
  • Psoríase
  • Quem somos
  • Regeneração epidérmica
  • Saúde animal e medicina veterinária
  • Quimioinformática, screening virtual in silico & caracterização fitoquímica

Categoria

  • Bioanalysis & bioengineering
  • Histology
  • in silico
  • Non classé
© Copyright 2019 - Bioalternatives - Legal disclaimer
  • Flickr
  • LinkedIn
  • Youtube
Scroll to top

Mot de passe oublié ?

Lost your password? Please enter your email address. You will receive mail with link to set new password.

Retour connexion

This site uses cookies only to collect information about how visitors use our site. By continuing to navigate this site, you accept our use of cookies.

OKLearn more

Cookie and Privacy Settings



How we use cookies

We may request cookies to be set on your device. We use cookies to let us know when you visit our websites, how you interact with us, to enrich your user experience, and to customize your relationship with our website.

Click on the different category headings to find out more. You can also change some of your preferences. Note that blocking some types of cookies may impact your experience on our websites and the services we are able to offer.

Essential Website Cookies

These cookies are strictly necessary to provide you with services available through our website and to use some of its features.

Because these cookies are strictly necessary to deliver the website, refuseing them will have impact how our site functions. You always can block or delete cookies by changing your browser settings and force blocking all cookies on this website. But this will always prompt you to accept/refuse cookies when revisiting our site.

We fully respect if you want to refuse cookies but to avoid asking you again and again kindly allow us to store a cookie for that. You are free to opt out any time or opt in for other cookies to get a better experience. If you refuse cookies we will remove all set cookies in our domain.

We provide you with a list of stored cookies on your computer in our domain so you can check what we stored. Due to security reasons we are not able to show or modify cookies from other domains. You can check these in your browser security settings.

Google Analytics Cookies

These cookies collect information that is used either in aggregate form to help us understand how our website is being used or how effective our marketing campaigns are, or to help us customize our website and application for you in order to enhance your experience.

If you do not want that we track your visit to our site you can disable tracking in your browser here:

Other external services

We also use different external services like Google Webfonts, Google Maps, and external Video providers. Since these providers may collect personal data like your IP address we allow you to block them here. Please be aware that this might heavily reduce the functionality and appearance of our site. Changes will take effect once you reload the page.

Google Webfont Settings:

Google Map Settings:

Google reCaptcha Settings:

Vimeo and Youtube video embeds:

Other cookies

The following cookies are also needed - You can choose if you want to allow them:

Accept settingsHide notification only