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Bioalternatives
  • Bioalternatives ——欢迎
    • 关于我们
    • 我们的团队
  • 化妆品
    • 保湿和皮肤屏障
    • 表皮再生
    • 皮肤色素沉着
    • 皮肤老化
    • 油性皮肤和皮脂分泌过盛
    • 皮肤保护和防御
    • 皮肤微生物群
    • 皮肤紧致和内聚力
    • 瘦身和脂肪细胞代谢
    • 皮肤微循环和血管化
  • 皮肤科
    • 痤疮
    • 头发生长和脱发
    • 特应性皮炎
    • 伤口愈合和皮肤再生
    • 银屑病,牛皮癣
    • 黑色素瘤
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皮肤紧致和内聚力

皮肤紧致和皱纹是最具特色的外部老化迹象。适当的细胞内聚力或细胞与细胞的粘附是年轻健康皮肤的主要特征。衰老改变细胞内聚力和细胞外基质的质量,这两者都会影响皮肤的紧致。

活性成分或化妆品化合物的作用之一是创造细胞内聚力,以防止紧致和弹性的丧失,并限制皱纹。可在体外评估不同的生物过程或机制:

  • 真皮内聚力和紧致的增强
  • 细胞外基质成分的产生及细胞与基质相互作用的改善
  • 皮肤与表皮连接质量及细胞粘附性的改善

皮肤紧致和内聚力: 体外模型和检测

Bioalternatives 有许多体外或离体模型可供您使用:

  • 正常人皮肤成纤维细胞(NHDF)
  • 真皮等效物(DE)
  • 正常人表皮角质形成细胞(NHEK)
  • 重建人表皮(RHE)
  • 全厚度再造皮肤(FTSK)
  • 皮肤外植体(离体)

在这些模型上,我们可通过衡量以下项来评估活性化合物或配方的效果:

  • 真皮内聚力和紧致(晶格收缩)
  • 细胞外基质成分的合成与表达:
    • 胶原蛋白(胶原蛋白I,胶原蛋白III)、弹性蛋白、纤维连接蛋白等
    • 蛋白多糖、糖氨基聚糖和透明质酸
    • 蛋白酶(MMPs)
  • 皮肤与表皮交界处蛋白质(整合素,层粘连蛋白V,胶原蛋白IV,胶原蛋白VII)
  • 细胞粘附蛋白质(桥粒芯糖蛋白等)
  • 细胞更新(增殖,分化)

这里是 Bioalternatives 在皮肤紧致和内聚力领域提出的所有测定方法中的几个例子:

  • Procollagen I synthesis

    NHDF, procollagen I synthesis/release (basal)

    1.00€
    加入购物车 Show Details
  • ECM gene expression

    NHDF, ECM gene expression (basal)

    1.00€
    加入购物车 Show Details
  • Collagen-IV-expression#Ctrl

    Skin maintained ex vivo, dermo-epidermal junction proteins expression (basal)

    1.00€
    加入购物车 Show Details
  • Lattice contraction

    DE, dermis strength and cohesion (basal)

    1.00€
    加入购物车 Show Details
  • Control

    NHDF, tropoelastin expression, ECM organization (basal)

    1.00€
    加入购物车 Show Details

了解我们所有与皮肤紧致和内聚力有关的标准测定方法

请直接访问目录

 

 

 

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Address

Bioalternatives, Inc.
250 Park Avenue, 7th Floor,
New York, NY, 10177, USA
Tel. +1 (212) 364 5115
Mail: info.us[@]bioalternatives.com

Bioalternatives SASU
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: info[@]bioalternatives.com

Latest posts

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页面

  • Bioalternatives ——欢迎
  • 人才招聘
  • 伤口愈合和皮肤再生
  • 体外药理学
  • 保湿和皮肤屏障
  • 免疫性炎症
  • 关于我们
  • 动物健康和兽医学
  • 化妆品
  • 化验和实验计划的开发和验证
  • 头发生长和脱发
  • 我们的团队
  • 油性皮肤和皮脂分泌过盛
  • 特应性皮炎
  • 痤疮
  • 瘦身和脂肪细胞代谢
  • 皮肤保护和防御
  • 皮肤微循环和血管化
  • 皮肤微生物群
  • 皮肤科
  • 皮肤紧致和内聚力
  • 皮肤老化
  • 皮肤色素沉着
  • 神经生物学
  • 组织学、免疫组织化学、免疫荧光
  • 细胞和组织工程
  • 表皮再生
  • 银屑病,牛皮癣
  • 黑色素瘤

Categories

  • Dermatologie
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