QIMA Life Sciences 具有以下体外或离体模型供您使用:
- 人类卵泡真皮乳头成纤维细胞(HFDPC)
- 人类毛囊(离体)
在这些模型上,我们可通过衡量以下项来评估活性化合物对脱发和头发生长的效果:
- 头发生长刺激(头发再生)
- 毛发生长抑制(抗毛发生长)
- 培养细胞活力的增加(抗凋亡,抗脱发)
- 毛干直径的增加
- 5-α 还原酶活性(雄激素代谢)
- 毛球/毛干色素沉着
- 特异性标志物表达(Ki67,TGK,纤连蛋白,β-连环蛋白,细胞因子等)
以下是 QIMA Life Sciences 在头发生长和脱发领域提出的所有标准测定中的几个例子:
Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
Dermatologie, Dermatology, Hair follicleDandruff is a common scalp disorder with multiple microbial and host-related factors contributing to its aetiology, including alterations in scalp sebum.
Canities and hair pigmentation
Cosmetics_cat_publi, Hair follicleCanities (hair greying) has a wide-ranging social and cosmetic impact. QIMA Life Sciences is focusing on its physiopathology, underlying causes and treatments.
Hair: Follicle, Associated Structures and Growth
Cosmetics_cat_publi, Hair follicleHair follicles are skin adnexa which are able to regenerate in a complete, autonomous, cyclic and asynchronous manner. The histological analysis of the pilosebaceous unit reveals a three-element organization: the epithelial compartment, the mesenchymal compartment and the sebaceous gland.